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Angiogenin is a small protein that exhibits pro-angiogenic activity. Angiogenin stimulates development of new blood vessels and cleaves RNA similarly to RNase enzymes. Angiogenin binds actin on endothelial cells, increasing protease production and degrading basement membrane connective tissues to allow cell migration and invasion.

References PubMed ID::

Cas No.




Formula Wt.

14.4 kDa


Angiogenic factor (human adenocarcinoma HT-29)

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Leland PA, Staniszewski KE, Park C, et al. The ribonucleolytic activity of angiogenin. Biochemistry. 2002 Jan 29;41(4):1343-50. PMID: 11802736.