The rational design and synthesis of metal-organic frameworks (MOFs) with well-controlled interpenetration represent a significant frontier in materials science, particularly for applications involving porosity and guest-host interactions. In this study, we report the first systematic investigation of interpenetration control in thorium-based MOFs using ligand steric modulation. The inherent “hardness” of the Th⁴⁺ cation, combined with strategic aromatic substitutions and fine-tuned synthetic conditions, enabled the crystallization of seven new thorium MOFs (Th-SINAP-n, n = 16–22) featuring five distinct topologies. Solvothermal reactions between Th(NO₃)₄ and triphenyl H₂TPDC under varying conditions yielded exclusively an interpenetrated framework with a hex topology—designated Th-SINAP-16.1948273-02-6 SMILES Introducing two methyl groups onto the TPDC linker to form 2,5-Me₂TPDC²⁻ and 2,2-Me₂TPDC²⁻ led to two noninterpenetrated UiO-68-type Th-MOFs—Th-SINAP-17 and Th-SINAP-20—both exhibiting record-high pore volumes of 74.8% and 75.3%, respectively, surpassing all previously reported thorium MOFs. Additionally, four more Th-MOFs (Th-SINAP-18, 19, 21, and 22) were obtained via modulated syntheses, revealing three different structural motifs. Notably, Th-SINAP-16 and Th-SINAP-21 are among the rare interpenetrated thorium MOFs documented to date. These results highlight unprecedented structural diversity and synthetic accessibility in Th-MOFs, which stem from the unique soft nature of Th⁴⁺ that facilitates single-crystal formation and enables precise structural tuning. This platform offers a powerful avenue to explore structure-property relationships, especially in iodine adsorption—a critical application for nuclear waste remediation due to the high volatility and biological activity of radioactive iodine isotopes such as ¹²⁹I and ¹³¹I. The slightly radioactive character of thorium is negligible in this context given its much longer half-life (t₁/₂ = 1.405 × 10¹⁰ y) compared to these iodine isotopes. The resulting materials exhibit diverse N₂ and I₂ vapor adsorption capacities, with Th-SINAP-17 showing the highest iodine uptake at 1188 mg/g, correlating strongly with its large void volume and noninterpenetrated architecture.50-02-2 manufacturer In contrast, interpenetrated frameworks like Th-SINAP-16 and Th-SINAP-21 display faster initial adsorption kinetics, suggesting that interpenetration can enhance mass transfer despite reduced pore size.PMID:31424879 Raman spectroscopy confirms charge transfer between electron-rich organic linkers and I₂ molecules, evidenced by characteristic bands at ~108 cm⁻¹ (asymmetric I₃⁻ stretch) and ~165 cm⁻¹ (I₅⁻ signature), supporting strong host-guest interactions. Overall, this work establishes thorium MOFs as a highly tunable and structurally rich class of porous materials, where interpenetration control via ligand engineering provides a viable strategy to optimize performance in iodine capture and other advanced applications.MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Complement C1q tumor necrosis factor-related protein 1
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:Q9BXJ1
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:C1qTNF1
Uniprot :
Q9BXJ1
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
CDKL2 Antibody web Gosuranemab Description PMID:35052871 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Basigin
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:P26453
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:Bsg
Uniprot :
P26453
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
SYT4 Antibody manufacturer RRAD Antibody custom synthesis PMID:35260536 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Aflatoxin B1 aldehyde reductase member 2
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:Q8CG45
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:Akr7a2
Uniprot :
Q8CG45
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ATIC Antibody web 4-Hydroxynonenal Biological Activity PMID:35132632 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Angiopoietin-1
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:O18920
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:ANGPT1
Uniprot :
O18920
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Smoothelin Antibody Protocol 4-Methylquinaldine Autophagy PMID:35067193 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Activity-dependent neuroprotector homeobox protein
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:Q9H2P0
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:ADNP
Uniprot :
Q9H2P0
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
CD49D Antibody References FAK Antibody Protocol PMID:35244983 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
14-3-3 protein zeta/delta
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:P63103
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:YWHAZ
Uniprot :
P63103
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
PKN1 Antibody Data Sheet SOD2 Antibody Data Sheet PMID:35217056 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
C-telopeptide of Collagen alpha-1(I) chain
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:P02454
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:CTXI
Uniprot :
P02454
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
NMNAT1 Antibody Formula Pseudouridine Epigenetics PMID:34374463 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Product Name :
Rab GDP dissociation inhibitor alpha
Brief Description :
Recombinant Protein
Accession No. :
Uniprot ID:P21856
Calculated MW :
Target Sequence :
Storage :
Store at -20˚C. (Avoid repeated freezing and thawing.)
Application Details :
Storage Buffer:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)gene_full_name:GDI1
Uniprot :
P21856
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
PPP1CB Proteinmedchemexpress Syntenin-1 Antibody Formula PMID:35213178 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
Name :
Influenza A H1N1 (A/England/195/2009) Hemagglutinin Protein (HA1 Subunit) (His Tag)
Biological Activity :
Background :
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells’ sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Biological Activity :
Testing in progress
Expression Host :
H1N1
Source :
HEK293 Cells
Tag :
Protein Accession No. :
ACR15621.1
NCBI Gene ID :
Synonyms :
Synonyms :
Harvey rat sarcoma viral oncogene homolog
Amino Acid Sequence :
Molecular Weight :
The secreted recombinant HA1 subunit of influenza A H1N1 HA (A/England/195/2009 (H1N1)) comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. As a result of glycosylation, the apparent molecular mass of the protein is approximately 50-55 kDa in SDS-PAGE under reducing conditions.
Purity :
> 97 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the N-terminal segment (Met 1-Arg 344) of influenza A H1N1 (A/England/195/2009 (H1N1)) hemagglutinin (ACR15621.1) termed as HA1, was fused with a polyhistidine tag at the C-terminus. polyhistidine tag.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
References & Citations :
White JM, Hoffman LR, Arevalo JH, et al. Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin. In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.1997Suzuki Y.Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol. Pharm. Bull. 2005. Senne DA, Panigrahy B, Kawaoka Y, et al. Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis. 1996Donald J. Benton,Influenza hemagglutinin membrane anchor,PNAS,2018
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
PI3-Kinase p110α Antibody Autophagy BMS-986278 Protocol PMID:33990097 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com