FSL-1

Description:
FSL-1 is an experimental drug that is being studied to treat infectious diseases and autoimmune diseases. FSL-1 is a cationic polypeptide with chemoattractant properties, which may be useful in the treatment of HIV infection. It has been shown to inhibit the production of proinflammatory cytokines and chemokines, such as IL-6, TNF-α, IL-8, and MCP-1. FSL-1 also inhibits the activity of matrix metalloproteinases (MMPs), such as MMP-9. Furthermore, this compound has been shown to suppress the activation of NFκB and AP-1 in vivo and in vitro.

Uniprot :
Q9Y6W3

Description:
Ramoplanin is an antibiotic that belongs to the group of antimicrobial agents. It has been shown to inhibit a wide range of human pathogens, including gram-positive species. Ramoplanin inhibits bacterial growth by binding to the D-alanyl-D-alanine moiety in peptidoglycan precursors and inhibiting both cell wall synthesis and cell division. This drug has been shown to have long-term efficacy in vivo models and is active against human serum. The intramolecular hydrogen bonds between the two phenyl groups of ramoplanin are thought to be responsible for its high binding affinity for the D-alanyl-D-alanine moiety.

Uniprot :

Description:
9-Hydroxyellipticine Hydrochloride is a synthetic analog of the natural compound ellipticine. It inhibits the transcriptional regulation of growth factors and receptors, which may be related to its anticancer activity. 9-Hydroxyellipticine Hydrochloride has been shown to inhibit cellular growth by binding to single-stranded DNA, causing cell death. This drug also inhibits platelet-derived growth factor (PDGF) receptor phosphorylation, which causes acute lung inflammation in mice. 9-Hydroxyellipticine Hydrochloride has been shown to bind to the factor X receptor (FXR), inhibiting protein synthesis and cell growth in cultured cells. The diagnostic applications of this drug are currently being explored.

Uniprot :
P31996

Description:
MG 624 is a synthetic agonist of the α7 nicotinic acetylcholine receptor (α7nAChR). It has been shown to inhibit angiogenesis, which is the growth of new blood vessels from pre-existing ones. MG 624 binds to the α7nAChR and blocks its signaling pathways, which leads to an increase in acetylcholine levels. This drug has also been shown to have anti-angiogenic effects in animal models. MG 624 is not very effective against bladder cancer cells but does inhibit the growth of other types of cancer cells such as prostate, breast and colon cancer cells. MG 624 may be used for the treatment of various cancers or for diabetic retinopathy.

Uniprot :
Q9ULZ3

Description:
Taurodeoxycholic acid (TDCA) is a bile acid that is synthesized from cholesterol in the liver. TDCA is conjugated with glycine to form taurodeoxycholate, which is then secreted into the bile and aids in digestion. TDCA has been shown to induce apoptosis by activating the death receptor pathway and inhibiting protein synthesis. It also inhibits inflammation by suppressing the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6. Taurodeoxycholic acid has been shown to be useful in treating injury due to its ability to reduce dextran sulfate binding to tissue proteins, preventing tissue injury and cell death.

Uniprot :
O95274