Cardiogenol C

Description:
Cardiogenol C is a molecule derived from the bark of the Amazonian plant Ocotea pretiosa. Cardiogenol C has been shown to stimulate the growth of cardiac tissue in cell culture, and has been shown to have clinical relevance for diabetic patients with congestive heart failure. Cardiogenol C induces cellular dedifferentiation and differentiation, which may be due to its ability to activate the colony-stimulating factor (CSF) receptor on cardiac cells. Cardiogenol C also activates epidermal growth factor receptors (EGFR) and vascular endothelial growth factor receptors (VEGFR), leading to increased production of CSF and other molecules that are important for cardiac regeneration.

Uniprot :
O14896

Description:
Terpinen-4-ol is a natural compound that is found in essential oils such as tea tree oil. It has been shown to have antimicrobial activity against Gram positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae. Terpinen-4-ol has been shown to inhibit the production of proinflammatory cytokines and chemokines, which reduces inflammation and disease activity. The antimicrobial activity of terpinen-4-ol was evaluated by its ability to inhibit the growth of Hl-60 cells. This substance also inhibits the synthesis of DNA and protein by binding to penicillin-binding proteins (PBP) on the bacterial ribosome. Terpinen-4-ol has also been shown to be an effective inhibitor of cancer cell growth in a model system for squamous cell carcinoma.

Uniprot :
P48540

Description:
FSL-1 is an experimental drug that is being studied to treat infectious diseases and autoimmune diseases. FSL-1 is a cationic polypeptide with chemoattractant properties, which may be useful in the treatment of HIV infection. It has been shown to inhibit the production of proinflammatory cytokines and chemokines, such as IL-6, TNF-α, IL-8, and MCP-1. FSL-1 also inhibits the activity of matrix metalloproteinases (MMPs), such as MMP-9. Furthermore, this compound has been shown to suppress the activation of NFκB and AP-1 in vivo and in vitro.

Uniprot :
Q9Y6W3

Description:
Ramoplanin is an antibiotic that belongs to the group of antimicrobial agents. It has been shown to inhibit a wide range of human pathogens, including gram-positive species. Ramoplanin inhibits bacterial growth by binding to the D-alanyl-D-alanine moiety in peptidoglycan precursors and inhibiting both cell wall synthesis and cell division. This drug has been shown to have long-term efficacy in vivo models and is active against human serum. The intramolecular hydrogen bonds between the two phenyl groups of ramoplanin are thought to be responsible for its high binding affinity for the D-alanyl-D-alanine moiety.

Uniprot :

Description:
9-Hydroxyellipticine Hydrochloride is a synthetic analog of the natural compound ellipticine. It inhibits the transcriptional regulation of growth factors and receptors, which may be related to its anticancer activity. 9-Hydroxyellipticine Hydrochloride has been shown to inhibit cellular growth by binding to single-stranded DNA, causing cell death. This drug also inhibits platelet-derived growth factor (PDGF) receptor phosphorylation, which causes acute lung inflammation in mice. 9-Hydroxyellipticine Hydrochloride has been shown to bind to the factor X receptor (FXR), inhibiting protein synthesis and cell growth in cultured cells. The diagnostic applications of this drug are currently being explored.

Uniprot :
P31996