Ation. The present perform was performed by J-GZ in partial fulfillment in the requirements for containing the degree “Dr. rer. biol. hum.”Ethics statementThe studies involving human participants were reviewed and approved by Zunyi Health-related University. Written informed consent for participation was not needed for this study in accordance with the national legislation along with the institutional needs. Written informed consent was not obtained in the individual(s) for the publication of any potentially identifiable images or data integrated in this post.Conflict of interestMH and UG reports collaborations with Merck Serono (advisory function, speakers’ bureau, honoraria, travel costs, and analysis funding), MSD (advisory function, speakers’ bureau, honoraria, travel expenditures, and investigation funding), AstraZeneca (research funding), Novartis (study funding), BMS (advisory part, honoraria, speakers’ bureau), Teva (travel expenses).Epiregulin Protein site AHW is often a founder and shareholder of AW Healthcare Co. Ltd. The remaining authors declare that the investigation was performed within the absence of any industrial or financial relationships that could possibly be construed as a potential conflict of interest.Author contributionsConceptualization, J-GZ, AHW, HM, UG, S-HJ, and DS. Methodology, J-GZ, AHW, and FT. Validation, Y-ZC, BS, RF, MH, HM, UG, and J-GZ. Data curation, J-GZ, AHW, GS, S-SH, HM, SC, and UG. Writing–original draft preparation, AHW, HW, J-GZ, and HW. Writing–review and editing, UG, HM, BF, SC, DS, and MH. Visualization, J-GZ and HW. Supervision, HM, UG, J-GZ, and DS. Project administration, J-GZ, HM, UG, and RW. Funding acquisition, J-GZ, S-HJ, and AHW. All authors contributed towards the write-up and authorized the submitted version.Publisher’s NoteAll claims expressed in this short article are solely these from the authors and usually do not necessarily represent these of their affiliated organizations, or these from the publisher, the editors plus the reviewers. Any solution that might be evaluated in this short article, or claim that may perhaps be made by its manufacturer, is just not guaranteed or endorsed by the publisher.FundingThis investigation was funded by the National Natural Science Foundation of China (Grant No. 82060475), the National Organic Science Foundation of Guizhou Province (Grant Nos. [2020]1Z062, ZK2021-YB435, and ZK2022-YB632), Lian Yun Gang Shi Hui Lan Public Foundation (Grant No. HL-HS2020-Supplementary materialThe Supplementary Material for this short article could be identified online at: frontiersin.org/articles/10.3389/ fimmu.2022.961926/fullsupplementary-material
(2022) 20:59 Li et al. Cell Communication and Signaling doi.org/10.1186/s12964-022-00877-RESEARCHOpen AccessAIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance within a murine corneal alkali burn modelQingyu Li1,two, Xia Hua3, Liangpin Li1,two, Xueyan Zhou4, Ye Tian1,2, Yang Deng5, Min Zhang5, Xiaoyong Yuan1,two and Wei Chi5Abstract Background: Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction.CA125 Protein Synonyms NADPH oxidase four (NOX4) produces reactive oxygen species (ROS), top to an imbalance in nucleotide-binding oligomerization domain-like receptor household pyrin domain containing 3 (NLRP3) and NLR loved ones pyrin domain containing 6 (NLRP6) expression.PMID:24834360 The mechanisms of AIP1, NOX4, ROS and inflammasomes in corneal neovascularization had been studied herein. Strategies: C57BL/6 and AIP1-knockout mice were utilized within this study. The alkali burn process was performed on.
