PHT-427
PHT-427 is an inhibitor of PDK1 and Akt that exhibits anticancer chemotherapeutic activity, inhibiting tumor growth in animal models of breast cancer and non-small cell lung cancer (NSCLC).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954073
| Cas No. |
1191951-57-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H31N3O2S2 |
| Formula Wt. |
409.61 |
| IUPAC Name |
4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide |
| Synonym |
PHT427 |
| Appearance |
White Crystal Powder |
Meuillet EJ, Zuohe S, Lemos R, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17. PMID: 20197390.
