Guanylin, human
Guanylin, human Guanylin is a gastrointestinal peptide hormone that activates guanyl cyclase C primarily in intestinal epithelial cells, but also in neurons. Guanylin increases intracellular levels of cGMP and induces…
June 2017
Guaifenesin
Guaifenesin Guaifenesin is an expectorant that alleviates symptoms of mucus accumulation. Guaifenesin inhibits mucin production, increases mucociliary transport, and decreases the viscoelasticity of mucus in airway epithelial cells. References PubMed…
GTPL-5846
GTPL-5846 GTPL-5846 activates GPR84, exhibiting pro-inflammatory activity. This compound increases chemotaxis of polymorphonuclear leukocytes and macrophages and stimulates production of pro-inflammatory cytokines. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929686 Cas No. 83797-69-7 Purity ≥98%…
GSK-690693
GSK-690693 GSK-690693 is an inhibitor of Akt that displays anticancer chemotherapeutic activity. In lung and colon cancer cells, GSK-690693 inhibits cell growth. In animal models of osteosarcoma, this compound increases…
GSK-461364
GSK-461364 GSK-461364 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for solid tumor cancers. GSK-461364 displays anticancer chemotherapeutic activity as…
GSK-429286A
GSK-429286A GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats. References PubMed…
GSK-343
GSK-343 GSK-343 is an inhibitor of enhancer of zeste homolog 2 (EZH2) histone methyltransferase (HMT). GSK-343 exhibits anticancer activity, inhibiting cell invasion and cell growth in epithelial ovarian cancer cells.…
GSK-2830371
GSK-2830371 GSK-2830371 is an inhibitor of wild-type p53-induced phosphatase 1 (Wip1) that exhibits anticancer chemotherapeutic activity. In animal models of lymphoma, GSK-2830371 inhibits cell growth and tumor growth. In neuroblastoma…
GSK-2636771
GSK-2636771 GSK-2636771 is an inhibitor of the p110β isoform of PI3K. GSK-2636771 displays anticancer chemotherapeutic activity in PTEN-deficient cancers such as glioblastomas, prostate cancers, and endometrial cancers. This compound is…
GSK-2606414
GSK-2606414 GSK-2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-α kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK-2606414 exhibits anticancer chemotherapeutic benefit, inhibiting…