GTPL-5846
GTPL-5846 activates GPR84, exhibiting pro-inflammatory activity. This compound increases chemotaxis of polymorphonuclear leukocytes and macrophages and stimulates production of pro-inflammatory cytokines.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929686
| Cas No. |
83797-69-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H21N3O2 |
| Formula Wt. |
239.32 |
| IUPAC Name |
6-(Octylamino)-2,4(1H,3H)-pyrimidinedione |
| Synonym |
6-n-octylaminouracil; 6-OAU |
Suzuki M, Takaishi S, Nagasaki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. PMID: 23449982.
