Irinotecan Hydrochloride Trihydrate Irinotecan is an analog of camptothecin that is used clinically to treat colon and ovarian cancers, among others. Irinotecan exhibits anticancer chemotherapeutic, anti-angiogenic, and immunosuppressive activities. Irinotecan…
Irsogladine Maleate Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of…
Isatin Isatin is an indole derivative found in Isatis, Calanthe, and Couroupita that exhibits anti-inflammatory, antioxidative, neuromodulatory, and anticancer chemotherapeutic activities. Isatin prevents TNBS-induced increases in TNF-α, COX-2, and PGE2…
Isobavachalcone Isobavachalcone is a prenylated chalcone flavonoid found in several species of Psoraleae; it exhibits neuroprotective, antithrombotic, antifungal, anticancer chemotherapeutic, and chemopreventive activities. In separate in vitro experiments, isobavachalcone inhibits…
Isoflurane Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane…
Isoimperatorin Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation…
Isoindigo Isoindigo inhibits proliferation in various leukemia and cancer cell lines, displaying anticancer activity. Isoindigo and its derivatives may also bind the aryl hydrocarbon receptor (AhR). Additionally, similar compounds show…
Isoliquiritigenin, natural Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylases (HDACs), VEGFR2, and NF-κB…
Isoniazid Isoniazid is an antibacterial compound that displays efficacy against Mycobacterium and is clinically used to treat tuberculosis. Isoniazid inhibits InhA, an NADH-dependent enoyl-coA reductase. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18932224 Cas No.…
Isopropyl Thiogalactoside Isopropyl thiogalactoside is an analog of galactose that is not cleaved by β-galactosidase. Isopropyl thiogalactoside is a mimic of allolactose that induces activation of the lac operon, simulating…