Isoproterenol Hydrochloride Isoproterenol is a non-selective β-adrenergic receptor agonist that is clinically used to treat bradycardia, heart block, and asthma; it exhibits antihypertensive, bronchodilatory, and anti-asthma activities. Isoproterenol increases systolic…
Isorhamnetin Isorhamnetin is a flavonol found in Tagetes that exhibits anti-obesity, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Isorhamnetin decreases levels of PPARγ, CEBPα, LXRα, and lipoprotein lipase in adipocytes.…
Isosorbide Mononitrate Isosorbide is a diuretic, vasodilator, and antihypertensive that acts as a NO donor. Isosorbide is clinically used to treat hydrocephalus, glaucoma, and angina pectoris. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1893408 Cas…
Isoxanthohumol Isoxanthohumol (IX) is a prenylflavinoid and derivative of xanthohumol found in Humulus lupulus. IX, similar to xanthohumol, exhibits anti-inflammatory, anti-angiogenic, and pro-apoptotic activities, although at a lesser potency than…
Isradipine Isradipine is a second-generation dihydropyridine calcium channel blocker. It has been found to protect against stroke and brain ischemia in rat models of hypertension. Research has also shown that…
Istradefylline Istradefylline is a competitive inhibitor of adenosine A2A receptors that exhibits tremorlytic activity. Istradefylline is currently under examination as a potential treatment for Parkinson’s disease, as it decreases “off”…
Itopride Hydrochloride Itopride is an inhibitor of acetylcholinesterase (AChE) and D2 receptors; it exhibits prokinetic gastrointestinal motility modulating activity. Itopride is clinically used to treat functional dyspepsia and gastroesophageal reflux…
Itraconazole Itraconazole is a triazole antifungal that also exhibits anti-angiogenic and anticancer chemotherapeutic activities. Itraconazole inhibits synthesis of ergosterol, preventing fungal cell wall formation in Aspergillus. Itraconazole also inhibits hedgehog…
Ivermectin Ivermectin is an avermectin-family antibiotic that exhibits anti-parasitic/anti-helminthic activity. Ivermectin activates glutamate-gated Cl- channels, interfering with neurotransmission and muscle function in arthropods and nematodes. At high doses, ivermectin also…
IWP-2 IWP-2 is an inhibitor of PORCN that inhibits Wnt signaling, exhibiting anticancer activity. IWP-2 increases activity of caspases 3 and 7, inhibiting proliferation, migration, and invasion of gastric cancer…