Isoimperatorin Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation…
Isoflurane Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane…
Isobavachalcone Isobavachalcone is a prenylated chalcone flavonoid found in several species of Psoraleae; it exhibits neuroprotective, antithrombotic, antifungal, anticancer chemotherapeutic, and chemopreventive activities. In separate in vitro experiments, isobavachalcone inhibits…
Isatin Isatin is an indole derivative found in Isatis, Calanthe, and Couroupita that exhibits anti-inflammatory, antioxidative, neuromodulatory, and anticancer chemotherapeutic activities. Isatin prevents TNBS-induced increases in TNF-α, COX-2, and PGE2…
Irsogladine Maleate Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of…
Irinotecan Hydrochloride Trihydrate Irinotecan is an analog of camptothecin that is used clinically to treat colon and ovarian cancers, among others. Irinotecan exhibits anticancer chemotherapeutic, anti-angiogenic, and immunosuppressive activities. Irinotecan…
Irinotecan Irinotecan is an analog of camptothecin that is used clinically to treat colon and ovarian cancers, among others. Irinotecan exhibits anticancer chemotherapeutic, anti-angiogenic, and immunosuppressive activities. Irinotecan inhibits DNA…
Irbesartan Irbesartan is an angiotensin II type 1 (AT1) receptor inhibitor that also activates PPARγ receptors; it exhibits antihypertensive, cardioprotective, and anti-hyperlipidemic activities. In angiotensin-converting enzyme 2 (ACE2)-deficient mice, irbesartan…
Ipriflavone Ipriflavone is a synthetic isoflavone that exhibits anti-osteoporotic, anti-resorptive, and cytoprotective activities. In animal models of low Ca2+ diet, ipriflavone decreases bone resorption and increases bone density and volume.…
IPI-145 IPI-145 is an inhibitor of p110δ PI3K that exhibits anticancer chemotherapeutic, immunosuppressive, and anti-inflammatory activities. In clinical trials, IPI-145 displays potential benefit in the treatment of chronic lymphocytic leukemia…