Istradefylline Istradefylline is a competitive inhibitor of adenosine A2A receptors that exhibits tremorlytic activity. Istradefylline is currently under examination as a potential treatment for Parkinson’s disease, as it decreases “off”…
Isradipine Isradipine is a second-generation dihydropyridine calcium channel blocker. It has been found to protect against stroke and brain ischemia in rat models of hypertension. Research has also shown that…
Isoxanthohumol Isoxanthohumol (IX) is a prenylflavinoid and derivative of xanthohumol found in Humulus lupulus. IX, similar to xanthohumol, exhibits anti-inflammatory, anti-angiogenic, and pro-apoptotic activities, although at a lesser potency than…
Isosorbide Mononitrate Isosorbide is a diuretic, vasodilator, and antihypertensive that acts as a NO donor. Isosorbide is clinically used to treat hydrocephalus, glaucoma, and angina pectoris. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1893408 Cas…
Isorhamnetin Isorhamnetin is a flavonol found in Tagetes that exhibits anti-obesity, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Isorhamnetin decreases levels of PPARγ, CEBPα, LXRα, and lipoprotein lipase in adipocytes.…
Isoproterenol Hydrochloride Isoproterenol is a non-selective β-adrenergic receptor agonist that is clinically used to treat bradycardia, heart block, and asthma; it exhibits antihypertensive, bronchodilatory, and anti-asthma activities. Isoproterenol increases systolic…
Isopropyl Thiogalactoside Isopropyl thiogalactoside is an analog of galactose that is not cleaved by β-galactosidase. Isopropyl thiogalactoside is a mimic of allolactose that induces activation of the lac operon, simulating…
Isoniazid Isoniazid is an antibacterial compound that displays efficacy against Mycobacterium and is clinically used to treat tuberculosis. Isoniazid inhibits InhA, an NADH-dependent enoyl-coA reductase. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18932224 Cas No.…
Isoliquiritigenin, natural Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylases (HDACs), VEGFR2, and NF-κB…
Isoindigo Isoindigo inhibits proliferation in various leukemia and cancer cell lines, displaying anticancer activity. Isoindigo and its derivatives may also bind the aryl hydrocarbon receptor (AhR). Additionally, similar compounds show…