AZD-8055
AZD-8055 AZD-8055 is an ATP-competitive mTORC1/2 inhibitor that exhibits immunosuppressive and anticancer chemotherapeutic activities. AZD-8055 promotes antibody class switching in B cells at low doses and decreases B cell proliferation…
June 2017
AZD-7762 Hydrochloride
AZD-7762 Hydrochloride AZD-7762 is an inhibitor of checkpoint kinase 1 (Chk1) that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a…
AZD-6482
AZD-6482 AZD-6482 is an inhibitor of p110β PI3K. AZD-6482 inhibits insulin-induced adipocyte glucose uptake in vitro and increases glucose homeostasis in vivo. Additionally, AZD-6482 exhibits antithrombotic activity without increasing bleeding…
Atriopeptin III
Atriopeptin III Atriopeptin III is an analog of atrial natriuretic peptide (ANP) that exhibits vasodilatory/hypotensive and diuretic activities. In rat kidneys, atriopeptin III increases the diameter of constricted afferent arterioles,…
Atglistatin
Atglistatin Atglistatin is an inhibitor of adipose triglyceride lipase (ATGL) that decreases fatty acid mobilization and prevents lipolysis. Atglistatin also prevents triglyceride accumulation after acute myocardial infarction, displaying cardioprotective benefit.…
Asperosaponin VI
Asperosaponin VI Asperosaponin VI is a triterpene saponin found in the Dipsacus asper plant. Asperosaponin VI displays cardioprotective and antioxidative activities. In animal models, this compound protects the heart from…
Asiatic Acid, 95%
Asiatic Acid, 95% Asiatic acid is a triterpene aglycone originally found in Centella; it exhibits cardioprotective, hepatoprotective, anti-inflammatory, antioxidative, antihypertensive, anticancer, anti-fibrotic, and anti-osteoporotic activities. In vitro and in vivo,…
Ascorbyl Palmitate
Ascorbyl Palmitate Ascorbyl palmitate is a fat-soluble vitamin C derivative that is commercially used as a vitamin C supplement and antioxidative food additive; it is also used in research models…
Ascomycin
Ascomycin Ascomycin is an ethyl analog of FK506 that was initially produced by species of Streptomyces. Ascomycin binds FK506 binding protein 12 and the resulting complex inhibits calcineurin/protein phosphatase 2B…
AS-703026
AS-703026 AS-703026 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. In vitro, AS-703026 inhibits proliferation of melanoma cells. In both in vitro and in vivo models of colorectal…