Uroguanylin, human Uroguanylin is an endogenous natriuretic peptide that modulates activity through Na+/H+ exchangers in intestinal and renal tissues, altering electrolyte and water transport. Uroguanylin activates guanylyl cyclase receptors to…
Usnic Acid Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma…
Valdecoxib Valdecoxib is a COX inhibitor specific for COX-2; it also inhibits carbonic anhydrase. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. In addition to…
Valsartan Valsartan is an angiotensin II (ATII) type 1 receptor (AT1) inhibitor that is clinically used to lower blood pressure and coronary resistance, and to decrease cardiac hypertrophy. Valsartan exhibits…
Vardenafil Dihydrochloride Vardenafil is a centrally-acting phosphodiesterase 5 (PDE5) inhibitor that is clinically used to treat erectile dysfunction. Vardenafil also exhibits antioxidative and antihypertensive activities and shows some potential for…
Vasoactive Intestinal Peptide Vasoactive intestinal peptide (VIP) is an endogenous peptide hormone that exhibits bronchodilatory, vasodilatory, and immunomodulatory activities. VIP increases levels of IL-10, Foxp3, and TGF-β in vivo and…
Vasoactive Intestinal Peptide, guinea pig Vasoactive intestinal peptide (VIP) exhibits bronchodilatory, vasodilatory, and immunomodulatory activities. VIP increases levels of IL-10, Foxp3, and TGF-β in vivo and prevents LPS-induced expression of…
Vatalanib Dihydrochloride Vatalanib is an inhibitor of VEGFR that is currently in clinical trials for the treatment of myelodysplastic syndrome, lymphomas, non-small cell lung cancers (NSCLCs), and other cancers. Vatalanib…
VE-821 VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.…
Vecuronium Bromide Vecuronium is a non-depolarizing muscle relaxant that inhibits nicotinic acetylcholine receptors (nAChRs), blocking neurotransmission at the neuromuscular junction. Vecuronium is clinically used as an anesthetic and paralytic during…