Romidepsin
Romidepsin Romidepsin is a depsipeptide prodrug that inhibits histone deacetylases (HDACs). Romidepsin is currently in clinical trials as a potential treatment for T-cell lymphomas; it displays anticancer chemotherapeutic and antiviral…
Ubiquitin Ligase- ubiquitin-ligase
Ropinirole Hydrochloride
Ropinirole Hydrochloride Ropinirole is an indoline agonist at D2/3 receptors that is clinically used to treat restless leg syndrome and Parkinson’s disease. Ropinirole prevents dopaminergic neuron damage and MPTP-induced changes…
Roscovitine
Roscovitine Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels; it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma…
Rosiglitazone
Rosiglitazone Rosiglitazone is a thiazolidinedione insulin sensitizer that activates PPARγ, decreasing blood glucose and insulin levels. Rosiglitazone exhibits anti-diabetic, anti-inflammatory, antioxidative, anticancer, anti-angiogenic, antihypertensive, and anti-fibrotic activities. In vivo, rosiglitazone…
Rosiglitazone Maleate
Rosiglitazone Maleate Rosiglitazone is a thiazolidinedione insulin sensitizer that activates PPARγ, decreasing blood glucose and insulin levels. Rosiglitazone exhibits anti-diabetic, anti-inflammatory, antioxidative, anticancer, anti-angiogenic, antihypertensive, and anti-fibrotic activities. In vivo,…
Rosmarinic Acid
Rosmarinic Acid Rosemarinic acid is a caffeic acid ester found in many plants, including Melissa, Salvia, Ocimum, Rosmarinus, and Origanum. Rosemarinic acid exhibits antidepressant, neuroprotective, anti-inflammatory, anti-allergic, anti-angiogenic, anti-fibrotic, and…
Rosuvastatin Calcium
Rosuvastatin Calcium Rosuvastatin is an inhibitor of HMG-CoA reductase that decreases serum LDL and VLDL and is used to treat atherosclerosis in clinical settings. In addition to anti-atherosclerotic benefit, rosuvastatin…
Rotenone
Rotenone Rotenone is a pesticide that exhibits genotoxic, pro-oxidative, and neurodegenerative properties. In vitro, rotenone induces formation of micronuclei and modifies the microtubule organizing centers of mitotic spindles. In other…
Roxatidine Acetate Hydrochloride
Roxatidine Acetate Hydrochloride Roxatidine is an antihistamine compound that inhibits H2 histamine receptors, exhibiting antacid and anti-ulcerative activities by preventing gastric acid secretion. Roxatidine also inhibits indomethacin-induced small intestinal injury…
Roxithromycin
Roxithromycin Roxithromycin is a semi-synthetic macrolide antibiotic that exhibits anti-inflammatory, anti-asthma, vasodilatory, antibacterial, and anti-arthritic activities; it binds to the 50S ribosome, inhibiting protein synthesis. In animal models of ovalbumin-induced…