Panaxatriol Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and…
Pancreastatin, pig Pancreastatin is an endogenous peptide derived from chromogranin-A that regulates insulin action, inhibiting insulin secretion and increasing glucagon secretion. Pancreastatin binds and inhibits GRP78, decreasing insulin-stimulated glucose uptake…
Pancreatic Polypeptide, chicken Pancreatic polypeptide is an endogenous neuropeptide Y-family hormone that exhibits anorexigenic activity. Pancreatic polypeptide binds the Y4 receptor to decrease food intake, increase locomotor activity, and stimulate…
Pancreatic Polypeptide, human Pancreatic polypeptide is an endogenous neuropeptide Y-family hormone that exhibits anorexigenic activity. Pancreatic polypeptide binds the Y4 receptor to decrease food intake, increase locomotor activity, and stimulate…
Pancuronium Bromide Pancuronium is a reversible, competitive inhibitor of post-synaptic nicotinic acetylcholine receptors (nAChRs) that acts as a non-depolarizing neuromuscular junction (NMJ) blocker. When used clinically, pancuronium induces skeletal muscle…
Pantoprazole Pantoprazole is an H+/K+ ATPase inhibitor that exhibits antacid, anti-parasitic, and anticancer chemotherapeutic activities. Pantoprazole is clinically used to treat gastroesophageal reflux disease (GERD), although its inhibition of ROCK-2…
Parathyroid Hormone-Related Protein (1-34), human/rat PTH (parathyroid hormone)-related protein (PTH-RP) binds the PTH1 receptor and exhibits anti-osteoporotic, anti-angiogenic, and pro-fibrotic activities. PTH (1-34) is an endogenous peptide that is clinically…
Paroxetine Hydrochloride Hemihydrate Paroxetine is a SSRI that primarily inhibits activity of the 5-HT transporter (SERT) but also displays some affinity for the norepinephrine transporter (NET) and for muscarinic acetylcholine…
Pelitinib Pelitinib is an irreversible EFGR inhibitor that exhibits anticancer chemotherapeutic benefit in the treatment of non-small cell lung cancer (NSCLC) and other solid tumor cancers. In vitro, pelitinib inhibits…
Penitrem A Penitrem A is a neuroactive mycotoxin initially produced by species of Penicillum. Penitrem A exhibits tremorgenic activity. In vitro and in vivo, penitrem A inhibits Ca2+/voltage-sensitive K+ (BK)…