Hyaluronic Acid Sodium Hyaluronic acid is an endogenous anionic non-sulfated glycosaminoglycan that is found in connective tissue, epithelial tissue, and synovial fluid. Hyaluronic acid exhibits pro-inflammatory activity, binding surface proteins…
Hydroxyurea Hydroxyurea exhibits anticancer chemotherapeutic and antiviral activities; it inhibits ribonucleotide reductase, limiting deoxyribonucleotide production and inhibiting DNA synthesis. This compound also treats sickle cell anemia, as it increases NO…
Hypocrellin A Hypocrellin A exhibits antibacterial and immunomodulatory activities. In vitro, hypocrellin A inhibits MHC II antigen presentation but not MHC I antigen presentation. Additionally, this compound increases levels of…
Hypothemycin Hypothemycin is a polyketide found in Setophoma that exhibits anticancer, antifungal, and anti-parasitic activities. Hypothemycin is a resorcyclic acid lactone. This compound inhibits cell survival in melanoma and colon…
Icariin Icariin is a flavonol glycoside originally found in Epimedium that exhibits vasodilatory, antidepressant, neuroprotective, antioxidative, and anti-osteoporotic activities. Icariin inhibits phosphodiesterase 5 (PDE5), increasing cGMP and NO concentrations. Icariin…
Icilin Icilin is an agonist at transient receptor potential melastatin 8 (TRPM8) channels; it may block transient receptor potential vanilloid 3 (TRPV3) channels. Icilin displays both hyperalgesic and analgesic activities…
Inauhzin Inauhzin is an inhibitor of SIRT1 that activates p53; it also inhibits inosine monophosphate dehydrogenase (IMPDH). Inauhzin exhibits anticancer chemotherapeutic activities, inducing apoptosis and suppressing cell growth in non-small…
INCB-28060 INCB28060 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. In cellular models of cancer, INCB28060 inhibits cell migration and induces apoptosis, inhibiting proliferation. In animal models, this…
INCB018424 INCB018424 is an inhibitor of JAK1/2 that is clinically used to treat rheumatoid arthritis and myelofibrosis. INCB018424 exhibits anticancer, anti-inflammatory, and antiviral activities. In myeloma cells, INCB018424 inhibits cell…
Indapamide Indapamide is a thiazide-like diuretic that exhibits antihypertensive and anti-fibrotic activities. Indapamide is clinically used to treat hypertension and heart failure. Indapamide blocks the slow component of delayed rectifier…