GSK-429286A GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats. References PubMed…
GSK-461364 GSK-461364 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for solid tumor cancers. GSK-461364 displays anticancer chemotherapeutic activity as…
GSK-690693 GSK-690693 is an inhibitor of Akt that displays anticancer chemotherapeutic activity. In lung and colon cancer cells, GSK-690693 inhibits cell growth. In animal models of osteosarcoma, this compound increases…
GTPL-5846 GTPL-5846 activates GPR84, exhibiting pro-inflammatory activity. This compound increases chemotaxis of polymorphonuclear leukocytes and macrophages and stimulates production of pro-inflammatory cytokines. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929686 Cas No. 83797-69-7 Purity ≥98%…
Guaifenesin Guaifenesin is an expectorant that alleviates symptoms of mucus accumulation. Guaifenesin inhibits mucin production, increases mucociliary transport, and decreases the viscoelasticity of mucus in airway epithelial cells. References PubMed…
Guanylin, human Guanylin is a gastrointestinal peptide hormone that activates guanyl cyclase C primarily in intestinal epithelial cells, but also in neurons. Guanylin increases intracellular levels of cGMP and induces…
Guanylin, rat/mouse Guanylin is a gastrointestinal peptide hormone that activates guanyl cyclase C primarily in intestinal epithelial cells, but also in neurons. Guanylin increases intracellular levels of cGMP and induces…
Guggulsterone Guggulsterone is a plant steroid obtained from myrrh that exhibits a wide variety of beneficial properties, including anti-metastatic, anticancer, anti-angiogenic, anti-fibrotic, antioxidative, anti-inflammatory, and anti-hyperlipidemic activities. In vitro, guggulsterone…
GW-5074 GW-5074 is an indole that functions as a highly selective Raf-1 (c-Raf) kinase inhibitor and is used to study Ras/Raf-1/ERK signaling. This compound inhibits desuccinylation activity of Sirt5 (a…
GW-788388 GW-788388 inhibits activin receptor-like kinase 5 (ALK5), suppressing TGF-β activity; it exhibits anti-fibrotic and cardioprotective activities. GW-788388 increases survival in studies of Trypanosoma infection and prevents Chagas disease-induced development…