Epoxiconazole Epoxiconazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, epoxiconazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, epoxiconazole may…
Eprinomectin Eprinomectin is a semi-synthetic avermectin that is clinically used to treat livestock and domestic animals; it exhibits anti-helminthic and anti-parasitic activities. Eprinomectin increases GABA release, causing neuromuscular paralysis in…
Eptifibatide Eptifibatide is an inhibitor of glycoprotein GP IIb/IIIa that exhibits antiplatelet/antithrombotic activity. Eptifibatide inhibits fibrinogen-mediated platelet aggregation and is clinically used to treat acute coronary syndrome. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1892020/…
EPZ-5676 EPZ-5676 is an inhibitor of DOT1L histone methyltransferase (HMT) that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells with MLL gene translocations, EPZ-5676 displays cytotoxicity; in similar…
EPZ005687 EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers.…
EPZ6438 EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic…
Erdosteine Erdosteine is a thiol derivative that is clinically used to treat bronchitis and chronic obstructive lung diseases; it exhibits mucolytic, antioxidative, and anti-inflammatory activities. In vitro, erdosteine inhibits H2O2-induced…
Ergosterol Ergosterol is a sterol component of cell membranes in yeast and fungi. Ergosterol is a target for many antifungal compounds. Ergosterol exhibits anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In…
Erlotinib Hydrochloride Erlotinib is an inhibitor of EGFR that exhibits anticancer chemotherapeutic benefit; it is currently in clinical trials for the treatment of colorectal cancer, non-small cell lung cancers (NSCLCs),…
Erucin Erucin is an isothiocyanate (ITC) and analog of sulforaphane found in cruciferous vegetables. Erucin exhibits antioxidative, anti-inflammatory, neuroprotective, anticancer chemotherapeutic, and chemopreventive activities. Like other ITCs, erucin induces phase…