Dimethyl Fumarate
Dimethyl Fumarate Dimethyl fumarate is a fumaric acid methyl ester that is clinically used to treat psoriasis and under investigation as a potential treatment for multiple sclerosis (MS). Dimethyl fumarate…
Ubiquitin Ligase- ubiquitin-ligase
Diminazene Aceturate
Diminazene Aceturate Diminazene is a diamidine compound that activates angiotensin-converting enzyme 2 (ACE2), opposing the effects of angiotensin II (AT II) and the AT1 receptor. Diminazene acts as an antibacterial…
Dinaciclib
Dinaciclib Dinaciclib inhibits CDK1/2/5/9, displaying anticancer chemotherapeutic activity. Dinaciclib is currently in clinical trials as a potential treatment for various cancers. In cellular models of acute leukemias, dinaciclib inhibits cell…
Diosgenin
Diosgenin Diosgenin is a steroidal saponin found in Dioscorea that exhibits anticancer, anti-inflammatory, neuroprotective, cognition enhancing, and anti-hyperlipidemic activities. In breast cancer cells, diosgenin inhibits cell migration, actin polymerization, Vav2…
Diosmetin
Diosmetin Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, anticancer, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases…
Diosmin
Diosmin Diosmin is a flavone found in Teucrium that exhibits neuroprotective, cardioprotective, antioxidative, anti-hyperlipidemic, anticancer, chemopreventive, and anti-inflammatory activities. Diosmin alleviates neurological deficits, decreases infarct volume, and upregulates expression of…
Diphenhydramine Hydrochloride
Diphenhydramine Hydrochloride Diphenhydramine is a first generation antihistamine that exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities. Diphenhydramine inhibits muscarinic acetylcholine receptors (mAChRs) and Na+ channels and acts as an…
Dipropyl Disulfide
Dipropyl Disulfide Dipropyl disulfide is an organosulfide found in Allium that exhibits antioxidative, anti-hyperlipidemic, and chemopreventive activities. Dipropyl disulfide induces phase II enzymes, increasing levels of glutathione-S-transferase in vitro. Dipropyl…
Dipropyl Sulfide
Dipropyl Sulfide Dipropyl sulfide is an organosulfide found in Allium that exhibits antioxidative, anti-hyperlipidemic, and chemopreventive activities. Dipropyl sulfide induces phase II enzymes, increasing levels of glutathione-S-transferase in vitro. Dipropyl…
Dipyridamole
Dipyridamole Dipyridamole is a non-selective inhibitor of phosphodiesterases (PDEs) that increases levels of cAMP and cGMP; it also inhibits adenosine deaminase. Dipyridamole exhibits vasodilatory, ati-thrombotic, and anti-inflammatory activities. In monocytes,…