Lete 5-HT2 Receptor Antagonist review inhibition of telomerase activity (Fig. 2) and hTERT expression (Fig. 3). Discussion
Lete inhibition of telomerase activity (Fig. 2) and hTERT expression (Fig. three). Discussion Our prior study demonstrated that CAUE exhibited potent cytotoxic effects on human B-cell leukemia NALM-6 cells, but not on standard human lymphocytes (six). Activated B cells exhibit considerably longer telomeres and increased telomerase activity (12). The present study aimed to investigate the cytotoxic mechanisms of CAUE in NALM-6 cells and, as shown in Fig. 1, CAUE exhibited preferential damage to DNA synthesis compared with RNA and protein synthesis. This indicated that CAUE directly affects the nucleus and impairs DNA synthesis, resulting inside the induction of apoptosis. Caffeic acid 5-HT2 Receptor Modulator review phenethyl ester is really a parent compound of CAUE and 1 of its pharmacological mechanisms of DNA damage requires the inhibition of nuclear element B (NF- B) (13). Caffeic acid derivatives block NF- B activation (7), and it has been hypothesized that NF- B inhibitory molecules are clinically beneficial as single therapeutic agents or in combination with classical chemotherapeutic agents for the remedy of hematological malignancies (14). Thus, CAUE may well inhibit NF- B in leukemia cells and harm DNA to trigger the induction of apoptosis. NF- B regulates hTERT expression by binding to a website 350-bp upstream on the translational initiation web page (15). Moreover, it has been reported that telomerase straight regulates NF- B-dependent genes in cancer cells (16). Therefore, there is a close correlation involving NF- B and telomerase activity. The outcomes in the present study indicate that CAUE inhibits telomerase activation by means of mediation of hTERT protein expression, hence, we hypothesize that the inhibition by CAUE is dependent on the inhibition of NF- B activation.In conclusion, CAUE inhibits DNA synthesis and suppresses telomerase activity. Targeting the inhibition of telomerase has been hypothesized to become useful for cancer chemotherapy resulting from its selectivity against malignant cells, thereby lowering side-effects. Telomerase inhibition is probably to become tested on humans in the future, as a way to treat lymphoid cancers, which includes B-cell leukemia (17). The observations of the present study could consequently help the improvement of therapeutic approaches for leukemia individuals.
Open Access Case ReportLaparoscopic removal of an intrauterine device from the sigmoid colonFatih anlikan1, Ouz Arslan2, Muhittin Eftal Avci3, Ahmet G men4 ABSTRACT Uterine wall perforation that is generally observed by means of the posterior wall on the uterus is the most seriouscomplicationofanintrauterinedevice(IUD).WepresentacaseoflaparoscopicremovalofanIUD fromthesigmoidcolonina31-years-oldfemalewhowasadmittedtohospitalwithahistoryofpelvicpain andabnormalvaginalbleedingforonemonth.ThedislocatedIUDwasremovedfromthesigmoidcolonof laparoscopicinterventionwithoutanycomplications. In conclusion, the therapy modality for the removal of a dislocated IUD is attainable by laparoscopic surgeryinselectedpatientswherethedislocatedIUDisaccessible. Essential WORDS: Dislocatedintrauterinedevice,Laparoscopicsurgery.doi: dx.doi.org/10.12669/pjms.311.Ways to cite this:anlikan F, Arslan O, Avci ME, G males A. Laparoscopic removal of an intrauterine device in the sigmoid colon. Pak J Med Sci 2015;31(1):214-216. doi: dx.doi.org/10.12669/pjms.311.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(creativecommons.org/licenses/by/3.0), whichpermitsunrestricteduse,distribution,andreproductioninanyme.
