ameters were described in table 1. VTE was situated while in the upper (n = 8/38.1 ) or lower limbs (n = 10/47.6 ), portal vein (n = 1/4.8 ), and pulmonary embolism (n = 1/4,8 ). Regarding presentation, six(28.6 ) have been incidental, two(9.5 ) malfunctioning CVC and 13(61.9 ) with common indicators of VTE. VTE was related with CVC in 10 (47.6 ) situations. The imply time in between CVC insertion and VTE diagnosis was 22,1 days (43.2). The suggest time involving symptoms/diagnosis was 2,five (.five) days. Threat TXB2 Compound things for VTE had been located in 95 in the kids (table 2). Corticosteroids and asparaginase had been the medicines extra frequently utilized in VTE sufferers (33.three and 4.8 vs. 22.1 and 0.one , respectively). Therapeutic anticoagulation was made use of only in 13 (61.9 ) patients, since of thrombocytopenia in those with cancer. TABLE one Demographic and possibility variables connected with VTE in children with and with out VTEPatients Mean Age SD Intercourse (F/M) Hospital Non VTE (N = 950) six.six five.three 399 / 551 VTE (N = 21) 6.4 5.three 7 /Boldrini 138 HC nursery 603 HC ICUBoldrini 9 HC nursery 6 HC ICU12 (57.1 ) four (19.0 ) 0 eight (38.1 ) eleven.8 33.3 14 (66.seven )Bed Immobilization Surgical treatment in the course of Hospitalization Trauma CVC Hospitalization Time (days) ICU612 (64.four ) 351 (36.9 ) 32 262 (27.six ) 33.three 704.four 307 (32.three )ABSTRACT597 of|TABLE two Chance aspects associated with VTEPatient ‘s Chance Factors Cancer Gastrointestinal Congenital Heart Illness Kidney Ailment PARP2 Biological Activity Neurological Illness Other folks 4 (19.0 ) 2 (9.five ) two (9.five ) 2 (9.five ) one (4.eight ) 3 (14.3 ) Thrombosis Risk Aspect Immobilization Infection Surgical procedure or Intravascular method ICU CVC 8 (38.1 ) 13 (61.9 ) 10 (47.six ) 9 (42.8 ) 14 (66.7 )Conclusions: Preliminary data from your first Brazilian VTE pediatric registry indicate it really is prevalent amongst hospitalized children, and largely connected to CVC. Supported by a grant of FAPESP, variety 2016/14172-6. Accredited by Ethics Investigate Committee of Unicamp.least three months. The appropriate nRVT with no IVC extension had a historical past of a preceding venous thromboembolism, recurrence while in the contralateral renal vein and was taken care of with therapeutic anticoagulation for eight months. Thrombophilia testing for this patient was unremarkable. The 2 suitable nRVT had renal atrophy at 1 yr stick to up. Conclusions: Neonatal RVT are rare occasions with variable clinical qualities and management strategies. An global regis-PB0806|A Potential Data Collection Making use of the Global Pediatric Thrombosis Network (IPTN) to comprehend the Epidemiology for your Growth of Neonatal Renal Vein Thrombosis G. Woods1; J. Motwani2; N. Sirachainan3; R. Berrueco 4; C.H. van Ommen5; A.KC Chantry to gather information could optimize the capability to have an understanding of nRVT chance components and suitable management approaches. Encouraging the global pediatric thrombosis local community to employ the IPTN (redcap.isth.org/surveys/s=FPEDL XEF9A) to collect patient data would assist during the improvement of a lot required worldwide tips for nRVT management.Aflac Cancer and Blood Disorders Center at Children’s Healthcare PB0807|A Case of a Pediatric Patient with Protein S Heerlen Polymorphism and Deep Venous Thrombosis M. Kacar; M. Bhatt McMaster University, Hamilton, Canada Background: Hereditary Protein S (PS) deficiency is definitely an autosomal dominant disorder with greater chance of venous thromboembolism (VTE), prevalent in 0.5 in the standard population. The PS Heerlen polymorphism is actually a uncommon mutation at codon 501 on the PS gene that was initially considered a variant of uncertain
