Verapamil Hydrochloride Verapamil is an inhibitor of L-type voltage-gated Ca2+ channels that exhibits antihypertensive, anti-arrhythmic, and cardioprotective activities; it is classified as a class IV anti-arrhythmic. Verapamil treats hypertension and…
Vemurafenib Vemurafenib is a first generation selective B-Raf inhibitor that has been approved for clinical use in treating unresectable or metastatic melanoma; it exhibits anticancer chemotherapeutic activity. Vemurafenib binds the…
Veliparib Veliparib is an oral poly(ADP-ribose) polymerase (PARP) inhibitor that shows anticancer chemotherapeutic and anti-inflammatory activities. Veliparib crosses the blood-brain barrier with a 3:1 plasma:brain drug ratio. Inhibition of PARP…
Vecuronium Bromide Vecuronium is a non-depolarizing muscle relaxant that inhibits nicotinic acetylcholine receptors (nAChRs), blocking neurotransmission at the neuromuscular junction. Vecuronium is clinically used as an anesthetic and paralytic during…
VE-821 VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.…
Vatalanib Dihydrochloride Vatalanib is an inhibitor of VEGFR that is currently in clinical trials for the treatment of myelodysplastic syndrome, lymphomas, non-small cell lung cancers (NSCLCs), and other cancers. Vatalanib…
Vasoactive Intestinal Peptide, guinea pig Vasoactive intestinal peptide (VIP) exhibits bronchodilatory, vasodilatory, and immunomodulatory activities. VIP increases levels of IL-10, Foxp3, and TGF-β in vivo and prevents LPS-induced expression of…
Vasoactive Intestinal Peptide Vasoactive intestinal peptide (VIP) is an endogenous peptide hormone that exhibits bronchodilatory, vasodilatory, and immunomodulatory activities. VIP increases levels of IL-10, Foxp3, and TGF-β in vivo and…
Vardenafil Dihydrochloride Vardenafil is a centrally-acting phosphodiesterase 5 (PDE5) inhibitor that is clinically used to treat erectile dysfunction. Vardenafil also exhibits antioxidative and antihypertensive activities and shows some potential for…
Valsartan Valsartan is an angiotensin II (ATII) type 1 receptor (AT1) inhibitor that is clinically used to lower blood pressure and coronary resistance, and to decrease cardiac hypertrophy. Valsartan exhibits…