Atglistatin Atglistatin is an inhibitor of adipose triglyceride lipase (ATGL) that decreases fatty acid mobilization and prevents lipolysis. Atglistatin also prevents triglyceride accumulation after acute myocardial infarction, displaying cardioprotective benefit.…
Asperosaponin VI Asperosaponin VI is a triterpene saponin found in the Dipsacus asper plant. Asperosaponin VI displays cardioprotective and antioxidative activities. In animal models, this compound protects the heart from…
Asiatic Acid, 95% Asiatic acid is a triterpene aglycone originally found in Centella; it exhibits cardioprotective, hepatoprotective, anti-inflammatory, antioxidative, antihypertensive, anticancer, anti-fibrotic, and anti-osteoporotic activities. In vitro and in vivo,…
Ascorbyl Palmitate Ascorbyl palmitate is a fat-soluble vitamin C derivative that is commercially used as a vitamin C supplement and antioxidative food additive; it is also used in research models…
Ascomycin Ascomycin is an ethyl analog of FK506 that was initially produced by species of Streptomyces. Ascomycin binds FK506 binding protein 12 and the resulting complex inhibits calcineurin/protein phosphatase 2B…
AS-703026 AS-703026 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. In vitro, AS-703026 inhibits proliferation of melanoma cells. In both in vitro and in vivo models of colorectal…
AS-605240 AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune…
AS-604850 AS-604850 is an inhibitor of p110γ PI3K that exhibits anti-inflammatory and immunosuppressive activities. In animal models of experimental autoimmune encephalitis (EAE), AS-604850 decreases the number of leukocytes infiltrated into…
AS-252424 AS-252424 is an inhibitor of p110γ PI3K that exhibits anti-inflammatory activity. In animal models of peritoneal inflammation, AS-252424 decreases leukocyte recruitment. In vascular smooth muscle cells, AS-252424 decreases endothelin…
Arvanil Arvanil is an agonist at transient receptor potential vanilloid 1 (TRPV1) channels and cannabinoid 1 (CB1) receptors. Arvanil exhibits antidepressant, hypertensive, immunosuppressive, anti-inflammatory, antiemetic, and anticancer activities. Arvanil decreases…