Diminazene Aceturate
Diminazene Aceturate Diminazene is a diamidine compound that activates angiotensin-converting enzyme 2 (ACE2), opposing the effects of angiotensin II (AT II) and the AT1 receptor. Diminazene acts as an antibacterial…
2017
Dimethyl Fumarate
Dimethyl Fumarate Dimethyl fumarate is a fumaric acid methyl ester that is clinically used to treat psoriasis and under investigation as a potential treatment for multiple sclerosis (MS). Dimethyl fumarate…
Dimethoxycurcumin
Dimethoxycurcumin Like its parent compound, curcumin, this curcuminoid exhibits anticancer, antioxidative, anti-inflammatory, and antibacterial activities. In breast cancer cells, dimethoxycurcumin alters mitochondrial membrane potential, decreases ATP synthase activity, and induces…
Dimebon Dihydrochloride
Dimebon Dihydrochloride Dimebon is an activator of AMPK, a potentiator of AMPA, and an inhibitor of L-type voltage-gated Ca2+ channels, NMDA receptors, H1/2 histamine receptors, α-adrenergic receptors, and 5-HT2C/5A/6 receptors.…
Diltiazem Hydrochloride
Diltiazem Hydrochloride Diltiazem is a benzothiazepine-type compound that acts as an inhibitor of L-type Ca2+ channels. Diltiazem exhibits anti-arrhythmic, anti-anginal, anti-inflammatory, and cardioprotective activities. In animal models, diltiazem inhibits expression…
Dihydrotanshinone
Dihydrotanshinone Dihydrotanshinone is found in Salvia that exhibits neuromodulatory, anticancer, anti-inflammatory, anti-allergic, anti-diabetic, antithrombotic, vasodilatory, antihypertensive, and anti-angiogenic activities. Dihydrotanshinone binds to the P-site of acetylcholinesterase (AChE), inhibiting its activity…
Dihydrosanguinarine
Dihydrosanguinarine Dihydrosanguinarine (DHS) is a benzophenanthridine alkaloid that is a metabolite of sanguinarine. This compound exhibits a wide variety of antimicrobial activities (anti-parasitic, antifungal, and antibacterial) as well as anticancer…
Dihydromyristicin
Dihydromyristicin Dihydromyristicin was originally found in umbelliferous plants such as parsley; it exhibits antioxidative and chemopreventive activities. Dihydromyristicin induces phase II enzymes and inhibits benzopyrene-induced carcinogenesis in vivo. References PubMed…
Dihydromethysticin
Dihydromethysticin Dihydromethysticin is a kavalactone originally found in Piper methysticum (kava plant) that exhibits antifungal, antiepileptic/anticonvulsant, neuroprotective, anticancer, and chemopreventive activities. This compound displays antimicrobial efficacy against species of Fusarium,…
Dihydrokainic Acid
Dihydrokainic Acid Dihydrokainic acid is an inhibitor of GLT-1, preventing cellular uptake of glutamate. Dihydrokainic acid exhibits neuromodulatory activity and may induce excitotoxicity and excessive NMDA receptor activation. In vivo,…