Disulfiram
Disulfiram Disulfiram is an inhibitor of aldehyde dehydrogenase that is clinically used to treat chronic alcohol dependence. Disulfiram prevents complete metabolism of alcohol, allowing acetaldehyde to build up. Disulfiram also…
2017
Disodium Cycloheptylaminomethylene Diphosphate
Disodium Cycloheptylaminomethylene Diphosphate Cycloheptylaminomethylene diphosphate is a bisphosphonate compound that inhibits squalene synthase and sterol biosynthesis in vitro and in vivo. In various immune cells, this compound increases caspase-mediated apoptosis.…
Dipyridamole
Dipyridamole Dipyridamole is a non-selective inhibitor of phosphodiesterases (PDEs) that increases levels of cAMP and cGMP; it also inhibits adenosine deaminase. Dipyridamole exhibits vasodilatory, ati-thrombotic, and anti-inflammatory activities. In monocytes,…
Dipropyl Sulfide
Dipropyl Sulfide Dipropyl sulfide is an organosulfide found in Allium that exhibits antioxidative, anti-hyperlipidemic, and chemopreventive activities. Dipropyl sulfide induces phase II enzymes, increasing levels of glutathione-S-transferase in vitro. Dipropyl…
Dipropyl Disulfide
Dipropyl Disulfide Dipropyl disulfide is an organosulfide found in Allium that exhibits antioxidative, anti-hyperlipidemic, and chemopreventive activities. Dipropyl disulfide induces phase II enzymes, increasing levels of glutathione-S-transferase in vitro. Dipropyl…
Diphenhydramine Hydrochloride
Diphenhydramine Hydrochloride Diphenhydramine is a first generation antihistamine that exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities. Diphenhydramine inhibits muscarinic acetylcholine receptors (mAChRs) and Na+ channels and acts as an…
Diosmin
Diosmin Diosmin is a flavone found in Teucrium that exhibits neuroprotective, cardioprotective, antioxidative, anti-hyperlipidemic, anticancer, chemopreventive, and anti-inflammatory activities. Diosmin alleviates neurological deficits, decreases infarct volume, and upregulates expression of…
Diosmetin
Diosmetin Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, anticancer, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases…
Diosgenin
Diosgenin Diosgenin is a steroidal saponin found in Dioscorea that exhibits anticancer, anti-inflammatory, neuroprotective, cognition enhancing, and anti-hyperlipidemic activities. In breast cancer cells, diosgenin inhibits cell migration, actin polymerization, Vav2…
Dinaciclib
Dinaciclib Dinaciclib inhibits CDK1/2/5/9, displaying anticancer chemotherapeutic activity. Dinaciclib is currently in clinical trials as a potential treatment for various cancers. In cellular models of acute leukemias, dinaciclib inhibits cell…