JAK2 Inhibitor V
JAK2 Inhibitor V JAK2 inhibitor V (Z3) is an inhibitor of JAK2 that exhibits anticancer activity. In erythroleukemia cells, this compound induces cell cycle arrest and suppresses cellular proliferation. References…
2017
J-147
J-147 J-147 is a phenyl hydrazide that exhibits neuroprotective and cognition enhancing activities. In vitro, this compound decreases neuronal loss, oxidative stress, and glutamate-induced neurotoxicity. J-147 also ameliorates memory impairment…
IWP-2
IWP-2 IWP-2 is an inhibitor of PORCN that inhibits Wnt signaling, exhibiting anticancer activity. IWP-2 increases activity of caspases 3 and 7, inhibiting proliferation, migration, and invasion of gastric cancer…
Ivermectin
Ivermectin Ivermectin is an avermectin-family antibiotic that exhibits anti-parasitic/anti-helminthic activity. Ivermectin activates glutamate-gated Cl- channels, interfering with neurotransmission and muscle function in arthropods and nematodes. At high doses, ivermectin also…
Itraconazole
Itraconazole Itraconazole is a triazole antifungal that also exhibits anti-angiogenic and anticancer chemotherapeutic activities. Itraconazole inhibits synthesis of ergosterol, preventing fungal cell wall formation in Aspergillus. Itraconazole also inhibits hedgehog…
Itopride Hydrochloride
Itopride Hydrochloride Itopride is an inhibitor of acetylcholinesterase (AChE) and D2 receptors; it exhibits prokinetic gastrointestinal motility modulating activity. Itopride is clinically used to treat functional dyspepsia and gastroesophageal reflux…
Istradefylline
Istradefylline Istradefylline is a competitive inhibitor of adenosine A2A receptors that exhibits tremorlytic activity. Istradefylline is currently under examination as a potential treatment for Parkinson’s disease, as it decreases “off”…
Isradipine
Isradipine Isradipine is a second-generation dihydropyridine calcium channel blocker. It has been found to protect against stroke and brain ischemia in rat models of hypertension. Research has also shown that…
Isoxanthohumol
Isoxanthohumol Isoxanthohumol (IX) is a prenylflavinoid and derivative of xanthohumol found in Humulus lupulus. IX, similar to xanthohumol, exhibits anti-inflammatory, anti-angiogenic, and pro-apoptotic activities, although at a lesser potency than…
Isosorbide Mononitrate
Isosorbide Mononitrate Isosorbide is a diuretic, vasodilator, and antihypertensive that acts as a NO donor. Isosorbide is clinically used to treat hydrocephalus, glaucoma, and angina pectoris. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1893408 Cas…