Nitroso(acetoxymethyl)methylamine This compound is a precursor of NNK found in tobacco smoke; it exhibits immunosuppressive, mutagenic, and carcinogenic activities. In alveolar and bronchial epithelial cells, this compound inhibits production of…
Nitrendipine Nitrendipine is an L-type calcium channel blocker which research has shown to have a potent inhibitory effect on human carboxylesterase, a member of the serine hydrolase family, in vitro.…
Nitisinone Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a…
Nitidine Chloride Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases…
Nisoldipine Nisoldipine is an L-type Ca2+ channel blocker which with long-term treatment can prevent the development of hypertension and cardiac hypertrophy in young spontaneously hypertensive rats. It is a dihydropyridine…
Nimustine Hydrochloride Nimustine is a nitrosourea compound that exhibits anticancer chemotherapeutic activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. This compound is clinically used to treat gliomas and may…
Nimorazole Nimorazole is a hypoxic modifier and radiosensitizer that exhibits anticancer and anti-parasitic activities. Nimorazole is clinically used to treat trichomoniasis. Nimorazole features a structure similar to that of other…
Nimodipine Nimodipine is an antagonist at L-type Ca2+ channels that exhibits antihypertensive, neuroprotective, neuromodulatory, cognition enhancing, and anti-inflammatory activities. In animal models of subarachnoid hemorrhage, nimodipine prevents cerebral ischemia and…
Nimesulide Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Nimesulide exhibits anti-inflammatory, analgesic, antipyretic, and anticancer activities. Nimesulide is clinically used to treat arthritis, acute pain, and dysmenorrhea.…
Nilotinib Nilotinib is a second-generation phenylamino pyridine tyrosine kinase inhibitor that is clinically used to treat Bcr-Abl-positive chronic myelogenous leukemia (CML). Nilotinib is an ATP-competitive inhibitor of Abl, c-Kit, and…