Nocodazole Nocodazole is an inhibitor of microtubule polymerization that exhibits anticancer and anti-parasitic activities. Nocodazole induces depolarization of the mitochondrial membrane, caspase activation, PARP cleavage, and apoptosis in chronic lymphocytic…
Nocistatin Nocistatin is a neuromodulatory peptide that exhibits antinociceptive, neuroprotective, and anxiogenic activities. Ca2+-sensitive (BK, IK, SK) K+ channels mediate the inhibitory action of nocistatin on muscle contractions in the…
Nociceptin Nociceptin is an endogenous neuropeptide that binds the nociceptin (NOP) receptor, considered the ‘fourth’ opioid receptor subtype. Nociceptin displays anti-opioid activity, modulating nociception and exhibiting anti-analgesic properties in vivo.…
Nobiletin Nobiletin is a polymethoxylated flavone derived from the peel of citrus fruits. Nobiletin displays anti-inflammatory, anticancer, antioxidative, neuroprotective, cognition enhancing, antidepressant, and anti-obesity properties. In vitro, Nobiletin decreases iNOS…
NMS-E628 NMS-E628 is an inhibitor of ALK anaplastic lymphoma kinase (ALK) and Ros1 and an antagonist at Trk receptors; it exhibits anticancer chemotherapeutic activity. Clinically, this compound suppresses tumor growth…
NMS-873 NMS-873 inhibits valosin-containing protein (VCP; p97/Cdc48p), an ATPase involved in endoplasmic reticulum-associated degradation. NMS-873 displays anticancer activity, activating the unfolded protein response, interfering with autophagy, and inducing cell death…
NMS-1286937 NMS-1286937 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for various cancers; it exhibits anticancer chemotherapeutic activity. In osteosarcoma…
NLG919 NLG919 is an inhibitor of indoleamine-2,3-dioxygenase (IDO). This compound displays anticancer chemotherapeutic activity, prolonging survival rates in animal models of glioblastoma. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949383 Cas No. 1402836-58-1 Purity ≥98%…
Nizatidine Nizatidine is an inverse agonist at histamine H2 receptors that exhibits antacid and immunostimulatory activities. Nizatidine shortens gastric emptying time in clinical settings. Additionally, this compound stimulates maturation of…
Nivalenol Nivalenol is a Fusarium type B trichothecene mycotoxin. Nivalenol is cytotoxic to leukocytes, inhibiting cell proliferation, increasing IL-8 secretion, and decreasing MCP-1 secretion in an NF-κB-dependent manner. In macrophages…