Orexin B, human Orexin B is an endogenous peptide neurotransmitter that activates orexin-2 receptors (OX2), controlling pituitary functions and increasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Orexin…
Opioid Receptor Antagonist Ac-RFMWMK-NH2 This acetalin peptide inhibits all opioid receptors with the greatest affinity for μ-opioid receptors (μORs) and the weakest affinity for δ-opioid receptors (δORs); it increases contractility…
Ondansetron Hydrochloride Dihydrate Ondansetron exhibits antiemetic, antidepressant, and anxiolytic activities; it is an antagonist at 5-HT3 receptors. Through downstream effects on 5-HT signaling, ondansetron decreases immobility time in the forced…
Omeprazole Omeprazole is a proton pump inhibitor (PPI) that acts as an antagonist at H+/K+ ATPases and is clinically used to treat gastroesophageal reflux disease (GERD), dyspepsia, and peptic ulcer…
Oltipraz Oltipraz is an activator of Nrf2 that exhibits anti-fibrotic, anti-diabetic, anti-parasitic, anti-angiogenic, and anticancer chemotherapeutic activities. Oltipraz induces phase II enzymes such as NADPH:quinone reductase. Oltipraz also displays efficacy…
Olsalazine Sodium Olsalazine is a prodrug of 5-aminosalicylate that exhibits anti-inflammatory and chemopreventive activities. Olsalazine is used in both human and veterinary medicine and most commonly treats ulcerative colitis. Olsalazine…
Olopatadine Hydrochloride Olopatadine hydrochloride is an antihistamine clinically used to treat allergic rhinitis and allergic conjunctivitis. This compound acts as a mast cell stabilizer, preventing histamine and TNF-α release from…
Olomoucine Olomoucine is a purine derivative that inhibits CDKs and exhibits anti-inflammatory, neuroprotective, and anticancer activities. In macrophages, olomoucine decreases levels of NO and iNOS and suppresses activation of NF-κB.…
Olmesartan Medoxomil Olmesartan medoxomil is an angiotensin II type 1 receptor (AT1) inhibitor that inhibits negative regulatory feedback on renin secretion, decreasing secretion of aldosterone and resulting in decreased peripheral…
Oligomycin A Oligomycin A is a macrolide antibiotic initially produced by several species of Streptomyces. Oligomycin A inhibits mitochondrial F1F0 ATP synthase, binding the F0 subunit, inhibiting ATP synthesis. Oligomycin…