Lofexidine Hydrochloride Lofexidine is an agonist at α2-adrenergic receptors that exhibits antihypertensive activity. Lofexidine is currently under examination as a treatment of opioid withdrawal. In animal models, lofexidine inhibits stress-induced…
Litorin Litorin is a bombesin-related peptide that binds bombesin receptors in vitro and in vivo. Litorin exhibits anorexigenic and thermo-modulatory activities. In vivo, litorin decreases food intake and body temperature.…
Lisinopril Dihydrate Lisinopril is an enalapril analog that inhibits angiotensin-converting enzyme (ACE), exhibiting antihypertensive, cardioprotective, and anti-fibrotic activities. Lisinopril is clinically used to treat hypertension, congestive heart failure (CHF), myocardial…
Linezolid Linezolid is an oxazolidinone antibiotic that exhibits antibacterial activity against gram positive bacteria. Linezolid binds to the A site of 23S rRNA on the 50S ribosomal subunit, inhibiting protein…
Lincomycin Hydrochloride Monohydrate Lincomycin is a lincosamide antibiotic found in Streptomyces. Lincomycin exhibits antibacterial activity by binding the bacterial 50S ribosome subunit, inhibiting peptidyl transferase, and inducing dissociation of peptidyl-tRNA…
Limonin Glucoside Limonin is a furanolactone found in fruits in the Citrus family. Limonin exhibits antioxidative, anti-inflammatory, hepatoprotective, anticancer, antiviral, anti-parasitic, and immunomodulatory activities. In animal models of hepatic ischemia/reperfusion,…
Limonin Limonin is a furanolactone found in fruits in the Citrus family. Limonin exhibits antioxidative, anti-inflammatory, hepatoprotective, anticancer, antiviral, anti-parasitic, and immunomodulatory activities. In animal models of hepatic ischemia/reperfusion, limonin…
Ligustrazine Hydrochloride Ligustrazine is also known as tetramethylpyrazine. Tetramethylpyrazine is a dihydropyrazine found in Ligusticum walliichi that exhibits neuromodulatory, antioxidative, cognition enhancing, nephroprotective, antifibrotic, anti-inflammatory, and anticancer chemotherapeutic activities. This…
LH846 LH846 is an inhibitor of casein kinase 1δ (CK1δ) that also displays activity against CK1α and CK1ε. In research models, this compound lengthens the circadian period. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18940262…
LGK-974 LGK-974 inhibits PORCN, suppressing Wnt signaling. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. LGK-974 inhibits proliferation and induces differentiation of pancreatic adenocarcinoma xenografts; it…