Losartan Potassium Losartan is an inhibitor of the angiotensin II type 1 (AT1) receptor that exhibits antihypertensive, anti-fibrotic, and nephroprotective activities. In animal models of obstructive nephropathy, losartan decreases levels…
Lornoxicam Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2. Lornoxicam exhibits both anti-inflammatory and analgesic activities. In vivo, lornoxicam decreases herpetic stromal keratitis induced by herpes…
Lopinavir Lopinavir is an HIV protease inhibitor that displays antiviral and anticancer activities. In vitro, lopinavir inhibits sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), decreasing intracellular Ca2+ levels. In vivo, lopinavir’s inhibition of…
Loperamide Hydrochloride Loperamide is a μ-opioid receptor (μOR) agonist that exhibits gastrointestinal motility modulating, anorexigenic, analgesic, and antinociceptive activities; it also potentially inhibits HCN channels. Loperamide is clinically used as…
Lonidamine Lonidamine inhibits glycolysis by inhibiting hexokinases; it exhibits anti-aging, anti-parasitic, and anti-fertility activities. Lonidamine increases lifespan in Caenorhabditis elegans, increasing stress resistance and promoting mitochondrial respiration by increasing levels…
Lomustine Lomustine is a nitrosourea alkylator that exhibits anticancer chemotherapeutic activity. Lomustine is clinically used to treat various forms of cancer and is one component of the “PCV” regimen. References…
Lomerizine Dihydrochloride Lomerizine is an inhibitor of voltage-gated L-type and T-type Ca2+ channels as well as transient receptor potential (TRP5) channels. Lomerizine is clinically used to treat migraine and vertigo.…
Lomeguatrib Lomeguatrib is an anticancer chemotherapeutic compound that is used as a pseudosubstrate for O6-methylguanine-DNA methyltransferase (MGMT), inactivating the enzyme and inhibiting DNA repair across many cancer cell lines. Lomeguatrib…
Lomefloxacin Hydrochloride Lomefloxacin is a fluoroquinolone antibiotic that is clinically used to treat respiratory and urinary tract infections; it displays antibacterial efficacy by inhibiting DNA gyrase and topoisomerase IV. Lomefloxacin…
Loganin Loganin is an iridoid glucoside found in the Cornus officialis plant. Loganin displays anti-inflammatory, antioxidative, cognition enhancing, and neuroprotective activities. Loganin inhibits β-secretase in vitro and increases performance in…