Montelukast Sodium Montelukast is an antagonist at cysteinyl leukotriene 1(CysLT1) receptors; it exhibits anti-allergic, anti-asthma, anti-inflammatory, analgesic, anti-tussive, and bronchodilatory activities. Montelukast is clinically used to treat allergic rhinitis and…
Moniliformin Moniliformin is a mycotoxin initially produced by species of Fusarium that can be found in grain and vegetable products. Moniliformin may damage myocardial tissue as a result of decreasing…
Monensin Sodium Monensin is a polyether antibiotic initially produced by Streptomyces that exhibits antibactieral and anti-parasitic activities. Monensin is commercially used in cattle feed; it acts as an ionophore, transporting…
Monastrol Monastrol is a pyrimidine derivative inhibitor of kinesin Eg5 that inhibits ATPase activity and bipolar spindle formation. Monastrol exhibits anticancer activity, activating the spindle checkpoint but also inducing mitotic…
Molsidomine Molsidomine is a NO donor that exhibits vasodilatory, cardioprotective, anti-atherosclerotic, and anticoagulant activities. Molsidomine inhibits PDGF-induced smooth muscle cell migration and proliferation and suppresses carotid artery neointima formation in…
Moguisteine Moguisteine is a non-narcotic anti-tussive compound that is used to prevent chronic cough. Moguisteine may derive its function through inhibition of rapidly-adapting irritant receptors or through activation of ATP-sensitive…
Moclobemide Moclobemide is a reversible inhibitor of MAO-A that exhibits antidepressant, anti-inflammatory, antinociceptive, and neuromodulatory activities. Moclobemide decreases immobility time in animals undergoing the forced swim test and suppresses LPS-induced…
MLN8237 MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential…
MLN2480 MLN2480 is an oral pan-Raf inhibitor designed to inhibit cell proliferation and survival. MLN2480 is currently in clinical trials and displays anticancer chemotherapeutic activity. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945538 Cas No.…
MLN-4924 MLN4924 acts as a Nedd8-activating enzyme inhibitor, blocking proteasomal cullin protein neddylation by Cullin-RING E3 ubiquitin ligases. As a result, these proteins accumulate, inducing cell cycle arrest, senescence, autophagy,…