Granisetron Hydrochloride Granisetron is an antagonist at 5-HT3 receptors that exhibits antiemetic and anti-inflammatory activities. Unlike most similar-acting antiemetics, granisetron does not effect the cytochrome p450 metabolizing system. In animal…
GPR GPR is a homolog of the fibrinogen E domain that exhibits antithrombotic and neuroprotective activities. GPR is a tripeptide originally found in species of Amaranthus; it inhibits fibrin assembly.…
Gossypol Acetic Acid Gossypol acetic acid (GA) exhibits anticancer chemotherapeutic, pro-oxidative, antioxidative, and antibacterial activities. GA inhibits Bcl-2/Bcl-xl, enhancing TRAIL/mitochondria-induced apoptosis in breast cancer cells. In animal models, GA delayed…
Gossypol Gossypol is a polyphenol found in Gossypium that exhibits anti-fertility, antimalarial, immunosuppressive, antiviral, and anticancer chemotherapeutic activities. Gossypol inhibits calcineurin, PKC, and other kinases. Gossypol is under consideration for…
Goserelin Acetate Goserelin acts as a peptide agonist at the gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH) receptor, stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)…
Gonadorelin Acetate Gonadorelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH). Gonadorelin acts as an agonist at the GnRH/LHRH receptor, inducing release of…
GNE-7915 GNE-7915 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). GNE-7915 exhibits neuroprotective activity and is in development as a potential treatment for neurodegenerative disorders such as Parkinson’s disease.…
Glycyrrhizic Acid Ammonium Trihydrate Glycyrrhizin is a triterpene glycoside found in Glycyrrhiza that exhibits antiviral, anti-inflammatory, nephroprotective, neuroprotective, anticancer, chemopreventive, and antioxidative activities. Glycyrrhizin is commercially used as a flavorant…
Glycylglutamine Glycylglutamine (GQ) is an endogenous β-endorphin-derived dipeptide that exhibits antioxidative, cardioprotective, anti-inflammatory, and neuromodulatory activities. In animal models of burn injury, GQ decreases serum creatine kinase, lactate dehydrogenase, and…
Glycoprotein 38 Glycoprotein 38 (gp38) is a transmembrane O-glycoprotein that maintains barrier function in high endothelial venules. In development, gp38 activates platelets to induce separation of lymphatic and blood vascular…