The integration of pharmacogenomics into clinical practice has revolutionized the approach to antiretroviral therapy, particularly in optimizing drug efficacy and minimizing toxicity. In older adults, where physiological changes compound drug…
We have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6. We now investigate how these proteins affect the single-channel…
The generation of defined neuronal subtypes from pluripotent stem cells remains a cornerstone in regenerative neuroscience. This study reports the development of a scalable, reproducible protocol to differentiate mouse embryonic…
The analysis of splicing patterns in the primary HIV-1 subtype B isolate P2149-3 has revealed unprecedented complexity in RNA processing, highlighting previously unrecognized mechanisms that may shape viral gene expression…
The integration of electronic systems into three-dimensional (3D) structures marks a transformative leap in robotics and smart device engineering. Traditional electronics, confined to flat, planar substrates, struggle to conform to…
The survival of cells with defective Smc5/6 complexes under replication stress depends on a delicate balance between DNA damage checkpoint signaling and the regulation of homologous recombination (HR) intermediates. While…
Retinal ganglion cells (RGCs) are the primary output neurons of the retina, transmitting visual information to the brain via the optic nerve. Their proper development and long-term survival depend on…
6-Hydroxydopamine (6-OHDA) is a potent neurotoxin used to model Parkinson’s disease (PD) due to its selective toxicity toward dopaminergic neurons. While it is well established that 6-OHDA induces oxidative stress…
Pulmonary infections caused by Pseudomonas aeruginosa remain a significant clinical challenge, particularly in patients with cystic fibrosis and diffuse panbronchiolitis. This opportunistic pathogen exhibits remarkable resistance to antibiotics and produces…
Heart failure remains a significant global health burden, affecting millions and contributing to high morbidity and mortality. The pathophysiology of heart failure involves multiple mechanisms, among which oxidative stress plays…