T2 Triol
T2 Triol T2 triol is a Fusarium trichothecene mycotoxin. In vitro, this compound displays significant cytotoxic activity, inducing breakdown of polyribosomes and inhibiting polypeptide chain elongation in eukaryotes. Additionally, T2…
Ubiquitin Ligase- ubiquitin-ligase
Tacrolimus
Tacrolimus Tacrolimus is a calcineurin inhibitor that exhibits immunosuppressive, anti-fibrotic, anti-inflammatory, and anti-allergic activities. Clinically, tacrolimus is used to treat atopic dermatitis and conjunctivitis. In vivo, tacrolimus inhibits synthesis of…
TAE-226
TAE-226 TAE-226 is an inhibitor of focal adhesion kinase (FAK) that exhibits anti-angiogenic and anticancer activities. In vitro, this compound inhibits angiogenesis, decreases the viability of cancer cells, and suppresses…
TAK-632
TAK-632 TAK 632 is a benzothiazole pan-Raf inhibitor that displays anticancer chemotherapeutic activity. TAK 632 induces dimerization of Raf but prevents kinase activity. This compound inhibits cellular proliferation of melanoma…
TAK-733
TAK-733 TAK-733 is an inhibitor of MEK that exhibits anticancer chemotherapeutic activity. In tumor explant models, TAK-733 induces tumor regression. In colorectal cancer cells and melanoma cells, this compound suppresses…
Tamibarotene
Tamibarotene Tamibarotene is an agonist at retinoic acid receptors (RARs) and is selective primarily for RARα/β. Tamibarotene exhibits neuroprotective, cognition enhancing, immunomodulatory, and anticancer chemotherapeutic benefits. Tamibarotene upregulates tropomysin-related kinase…
Tamoxifen Citrate
Tamoxifen Citrate Tamoxifen is a selective estrogen receptor modulator (SERM) that acts as an ER agonist in the endometrium and as an ER antagonist in breast tissue; it also inhibits…
Tamsulosin Hydrochloride
Tamsulosin Hydrochloride Tamsulosin is an α1-adrenergic receptor antagonist that is clinically used to treat benign prostatic hyperplasia (BPH). Tamsulosin inhibits peristaltic activity, increases bladder blood flow, and decreases bladder overactivity.…
Tandutinib
Tandutinib Tandutinib is an inhibitor of several kinases, including FMS-like tyrosine kinase 3 (FLT3), PDGFR, and Kit. Tandutinib exhibits anticancer chemotherapeutic and anti-angiogenic activities and currently shows mixed results in…
Tangeretin
Tangeretin Tangeretin is a polymethoxy flavonoid found in citrus fruits. This compound exhibits a wide variety of health-related benefits, including anti-inflammatory, anti-allergic, anti-diabetic, anti-osteoporotic, and anticancer activities. In an in…