PF-04217903 PF-04217903 is a triazolopyrazine inhibitor of c-MET that displays anticancer chemotherapeutic and anti-metastatic activities. PF-04217903 inhibits cell proliferation, invasion, and migration as well as tumor growth in various cancer…
PF-06447475 PF-06447475 inhibits leucine-rich repeat kinase 2 (LRRK2), exhibiting neuroprotective activity. In animal models of Parkinson’s disease, this compound suppresses neuroinflammation and neurodegeneration. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953056 Cas No. 1527473-33-1 Formula…
PFI-1 PFI-1 is an inhibitor of BET bromodomains (BRDs) that prevents the association of BET with histones; it acts as an acyl-lysine (Kac) mimetic inhibitor, binding the Kac site of…
Phallacidin Phallicidin is a phallotoxin found in Amanita phalloides that exhibits cytotoxic activity. Phallicidin binds F-actin and inhibits depolymerization; it locks adjacent subunits together, preventing actin ATP hydrolysis. Fluorescent-tagged conjugates…
Phalloidin Phalloidin is a phallotoxin found in Amanita phalloides that exhibits cytotoxic activity. Phalloidin binds F-actin and inhibits depolymerization; it locks adjacent subunits together, preventing actin ATP hydrolysis. Fluorescent-tagged conjugates…
Phellodendrine Phellodendrine is a quaternary base alkaloid found in the bark of Phellodendron. Phellodendrine exhibits immunosuppressive and anti-inflammatory activities. Phellodendrine inhibits local semisyngenic and allogenic graft-versus-host (GVH) reactions and suppresses…
Phenethyl Caffeate Phenethyl caffeate is a compound found in propolis, a mixture produced by bees. Phenethyl caffeate exhibits anti-inflammatory, anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity, and anticancer chemotherapeutic activities. In vitro, phenethyl…
Phenethyl Dimethyl Caffeate Phenethyl dimethyl caffeate (PEDMC) exhibits antiviral and immunomodulatory potential. Similar compounds display potential anticancer benefit as well. In vitro and in vivo, this compound may inhibit replication…
Phenethyl Glucosinolate Potassium Phenethyl glucosinolate is found in cruciferous vegetables; it is the parent compound of phenethyl isothiocyanate (PEITC). This compound exhibits antioxidative, anticancer chemotherapeutic, and chemopreventive activities. In vitro,…
Phenethyl Isothiocyanate Phenethyl isothiocyanate (PEITC) is found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and…