Olaparib
Olaparib Olaparib is an inhibitor of poly(ADP-ribose) polymerase (PARP 1/2) that prevents DNA repair. Olaparib displays benefit in clinical trials of BRCA mutation-harboring ovarian and breast cancers as well as…
Ubiquitin Ligase- ubiquitin-ligase
Oleanolic Acid
Oleanolic Acid Oleanolic acid is a triterpenoid originally found in Vigna angularis and Trigonella foenum-graecum. Oleanolic acid exhibits anticancer, anti-inflammatory, anti-allergic, anti-resorptive, and anti-osteoporotic activities. In hypertrophic scar fibroblasts, oleanolic…
Oligomycin
Oligomycin This product consists of a mixture of oligomycins A, B and C. Oligomycins are macrolide antibiotics that exhibit antibacterial activity. Oligomycins suppress oxidative phosphorylation in the mitochondria by inhibiting…
Oligomycin A
Oligomycin A Oligomycin A is a macrolide antibiotic initially produced by several species of Streptomyces. Oligomycin A inhibits mitochondrial F1F0 ATP synthase, binding the F0 subunit, inhibiting ATP synthesis. Oligomycin…
Olmesartan Medoxomil
Olmesartan Medoxomil Olmesartan medoxomil is an angiotensin II type 1 receptor (AT1) inhibitor that inhibits negative regulatory feedback on renin secretion, decreasing secretion of aldosterone and resulting in decreased peripheral…
Olomoucine
Olomoucine Olomoucine is a purine derivative that inhibits CDKs and exhibits anti-inflammatory, neuroprotective, and anticancer activities. In macrophages, olomoucine decreases levels of NO and iNOS and suppresses activation of NF-κB.…
Olopatadine Hydrochloride
Olopatadine Hydrochloride Olopatadine hydrochloride is an antihistamine clinically used to treat allergic rhinitis and allergic conjunctivitis. This compound acts as a mast cell stabilizer, preventing histamine and TNF-α release from…
Olsalazine Sodium
Olsalazine Sodium Olsalazine is a prodrug of 5-aminosalicylate that exhibits anti-inflammatory and chemopreventive activities. Olsalazine is used in both human and veterinary medicine and most commonly treats ulcerative colitis. Olsalazine…
Oltipraz
Oltipraz Oltipraz is an activator of Nrf2 that exhibits anti-fibrotic, anti-diabetic, anti-parasitic, anti-angiogenic, and anticancer chemotherapeutic activities. Oltipraz induces phase II enzymes such as NADPH:quinone reductase. Oltipraz also displays efficacy…
Omeprazole
Omeprazole Omeprazole is a proton pump inhibitor (PPI) that acts as an antagonist at H+/K+ ATPases and is clinically used to treat gastroesophageal reflux disease (GERD), dyspepsia, and peptic ulcer…