LBH-589
LBH-589 LBH-589 is a hydroxamic acid inhibitor of class I (1, 2, 3, and 11) histone deacetylases (HDACs) that is clinically used to treat multiple myeloma and is currently in…
Ubiquitin Ligase- ubiquitin-ligase
LCL-161
LCL-161 LCL-161 is a second mitochondria-derived activator of caspases (SMAC) mimetic that binds to cIAP1 and cIAP2 (members of the inhibitors of apoptosis family of proteins, often upregulated in many…
LDK378
LDK378 LDK-378 is an anaplastic lymphoma kinase (ALK) inhibitor that displays anticancer chemotherapeutic activity. LDK-378 is used to treat ALK-positive non-small cell lung cancer (NSCLC), particularly in subjects experiencing resistance…
Leflunomide
Leflunomide Leflunomide inhibits dihydroorotate dehydrogenase, preventing UMP formation and pyrimidine synthesis. Metabolites of leflunomide may inhibit various kinases such as JNK and JAK. Leflunomide is clinically used to treat rheumatoid…
Lenalidomide
Lenalidomide Lenalidomide displays anti-inflammatory, anti-angiogenic, immunosuppressive, and anticancer chemotherapeutic benefits in the treatment of multiple myeloma and myelodysplastic syndromes associated with chromosome 5q deletions. Lenalidomide is a derivative of thalidomide…
Leptin (116-130), mouse
Leptin (116-130), mouse Leptin (116-130) is an active peptide fragment of leptin that increases levels of luteinizing hormone and prolactin. Leptin is an endogenous peptide that binds leptin receptors; it…
Leptin (22-56), human
Leptin (22-56), human Leptin is an endogenous peptide that binds leptin receptors; it is involved in feeding behavior and energy homeostasis. Leptin exhibits anorexigenic, antihypertensive, and neuroprotective activities. Leptin induces…
Lercanidipine Hydrochloride
Lercanidipine Hydrochloride Lercanidipine is a dihydropyridine calcium channel blocker. It significantly countered wall thickening and luminal narrowing on small sized arteries. This compound and other similar dihydropyridine-type Ca2+ antagonists exert…
Letrozole
Letrozole Letrozole is an inhibitor of aromatase that prevents the formation of estrogens; it is clinically used to treat hormone-responsive breast cancer and infertility and to terminate pregnancy. Letrozole exhibits…
Leu-Enkephalin
Leu-Enkephalin Leu-enkephalin is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Met-enkephalin exhibits neuromodulatory, antinociceptive/analgesic, and gastrointestinal motility modulating activities. Like…