Glimepiride Glimepiride is a second generation sulfonylurea that exhibits anti-diabetic activity. Glimepiride inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion.…
Gliotoxin Gliotoxin was initially produced by the marine fungus Aspergillus and exhibits anticancer, immunosuppressive, and anti-fibrotic activities. In cervical cancer and chondrosarcoma cells, gliotoxin increases activation of caspases 3, 8,…
Glipizide Glipizide is a second generation sulfonylurea that exhibits anti-diabetic activity. Glipizide inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion.…
GLPG-0634 GLPG-0634 is a triazolopyridine that inhibits JAK1; it exhibits anti-inflammatory and immunomodulatory activities. GLPG-0634 prevents release of inflammatory cytokines and is currently under investigation as a potential treatment for…
Glucagon (19-29), human Glucagon (19-29) is also known as miniglucagon, an endogenous short peptide co-released with glucagon. Miniglucagon inhibits insulin secretion from pancreatic β-cells in a Ca2+-dependent manner. References PubMed…
Glucagon-like Peptide I (7-37) Glucagon-like peptide 1 (GLP-1) is an endogenous peptide hormone that binds GLP-1 receptors, increasing cAMP and insulin secretion. GLP-1 primarily exhibits anorexigenic, anti-diabetic, and gastrointestinal modulatory…
Glucagon-like Peptide I Amide (7-36), human Glucagon-like peptide 1 (GLP-1) is an endogenous peptide hormone that binds GLP-1 receptors, increasing cAMP and insulin secretion. GLP-1 primarily exhibits anorexigenic, anti-diabetic, and…
Glucagon-like Peptide II, human Glucagon-like peptide 2 (GLP-2) is an endogenous peptide hormone primarily synthesized in the intestine and pancreas. GLP-2 binds and activates the GLP-2 receptor, exhibiting vasodilatory, antihypertensive,…
Glucagon-like Peptide II, rat Glucagon-like peptide 2 (GLP-2) is an endogenous peptide hormone primarily synthesized in the intestine and pancreas. GLP-2 binds and activates the GLP-2 receptor, exhibiting vasodilatory, antihypertensive,…
Glucagon, human Glucagon is an endogenous pancreatic peptide hormone that binds glucagon receptors to increase glucose levels and counteract the effects of insulin. Glucagon is clinically used to treat severe…