Betulin
Betulin Betulin is a pentacyclic triterpene found in birch bark. This compound can induce apoptosis and inhibit angiogenesis, lending it a wide variety of functions, including anticancer, antiviral, anti-inflammatory, anti-fibrotic,…
Ubiquitin Ligase- ubiquitin-ligase
Betulin-3-Acetate
Betulin-3-Acetate Betulin-3-acetate is a pentacyclic triterpene. This compound exhibits antiviral activity and anticancer potential. Betulin-3-acetate is a close relative of betulin, which has anticancer, antiviral, anti-inflammatory, and antibacterial activity. It…
Betulinic Acid
Betulinic Acid Betulinic acid is a pentacyclic triterpene that exhibits antithrombotic, anti-atherosclerotic, antioxidative, anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic properties. Betulinic acid decreases expression of P-selectin and binding of PAC-1, preventing…
Bexarotene
Bexarotene Bexarotene is a retinoid compound that binds and activates retinoid X receptors (RXRs) and is approved to treat cutaneous T cell lymphoma. Bexarotene displays a wide variety of beneficial…
BEZ235
BEZ235 BEZ235 inhibits PI3K and mTORC1/2, exhibiting anticancer chemotherapeutic activity. In nasopharyngeal cancer cells, BEZ235 induces G1 phase cell cycle arrest and apoptosis; in similar animal models of nasopharyngeal or…
Bezafibrate
Bezafibrate Bezafibrate is a PPARα agonist that is clinically used to lower LDL and triglyceride levels and to increase HDL levels. Bezafibrate exhibits anti-hyperlipidemic, cardioprotective, anti-diabetic, anti-osteoporotic, and anticancer chemotherapeutic…
BI-2536
BI-2536 BI-2536 is a polo-like kinase 1 (PLK1) inhibitor that disrupts mitosis and cell division. BI-2536 exhibits anticancer activity and may induce apoptosis in cancer cells. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18843938 Cas…
BI-6727
BI-6727 BI-6727 is a polo-like kinase 1 (PLK1) inhibitor that exhibits anticancer activity. In vitro, BI-6727 induces apoptosis in acute myelogenous leukemia (AML) cells. This compound is currently in clinical…
Biapenem
Biapenem Biapenem is a carbapenem β-lactam antibiotic. Like other carbapenems, biapenem binds penicillin-binding proteins to inhibit bacterial cell wall synthesis. Biapenem exhibits broad spectrum antibacterial activity and is clinically used…
Bicalutamide
Bicalutamide Bicalutimide is an inhibitor of the androgen receptor that exhibits anticancer chemotherapeutic activity. With other anti-androgens, bicalutimide decreases levels of Bcl-2, Bcl-XL, caspase-3, and PARP, induces apoptosis, and inhibits…