**Background** Cystic fibrosis (CF) is a severe genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein functions as a chloride channel across…
A 51-year-old woman was diagnosed with essential thrombocythemia (ET) in 1995, presenting with a markedly elevated platelet count of 1240 × 10⁹/L and hypercellular bone marrow dominated by large, mature…
Natural antisense transcripts (NATs) represent a significant class of regulatory RNAs that exhibit sequence complementarity to other transcripts. These molecules are increasingly recognized for their roles in post-transcriptional gene regulation…
**Background** Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a critical role in maintaining the stability and function of numerous client proteins, many of which…
Hyaluronic acid (HA) has emerged as a cornerstone in regenerative medicine due to its exceptional biocompatibility, biodegradability, and intrinsic bioactivity. As a major component of the extracellular matrix (ECM), HA…
**Background** Autoinflammatory diseases are characterized by inappropriate activation of the innate immune system, leading to systemic inflammation and tissue damage. Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine that plays a…
Chronic exposure to elevated manganese levels is increasingly recognized as a significant risk factor for neurocognitive and motor impairments, particularly in children. Despite this, the cellular mechanisms underlying manganese toxicity…
**Background** The G protein-coupled receptor 84 (GPR84) is a receptor primarily expressed in immune cells and is activated by medium-chain fatty acids. Activation of GPR84 plays a critical role in…
**Background** Obesity is a complex, chronic disease characterized by excessive adipose tissue accumulation, which significantly increases the risk of cardiovascular diseases, type 2 diabetes, and metabolic syndrome. The management of…
**Background** Fluorescent labeling is a fundamental tool in biomedical research, enabling the visualization and tracking of biomolecules within complex biological systems. Among various labeling strategies, bioorthogonal chemistry has emerged as…