**Background** Metabolic disorders, such as obesity and muscle atrophy, as well as various malignancies, remain significant challenges in global healthcare. The regulation of energy homeostasis and cellular proliferation often involves…
**Background** Human Immunodeficiency Virus (HIV) is a retrovirus that attacks the immune system, specifically CD4+ T cells, leading to Acquired Immunodeficiency Syndrome (AIDS). The replication cycle of HIV involves the…
Apoptosis, or programmed cell death, is a tightly regulated process essential for maintaining cellular homeostasis and preventing uncontrolled proliferation. In cancer, evasion of apoptosis is a hallmark feature that enables…
The development of functional enzymes capable of operating effectively in human physiological environments is a cornerstone of modern biotechnology, particularly in the design of implantable biosensors and biofuel cells. In…
Intrauterine growth restriction (IUGR) is increasingly recognized as a condition with profound implications for fetal metabolic programming, predisposing individuals to insulin resistance, obesity, and cardiovascular disease in adulthood. Central to…
Despite the proven safety and efficacy of adeno-associated virus serotype 2 (AAV2) vectors in gene therapy, their clinical application is often limited by dose-dependent immune responses, particularly CD8+ T cell…
Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited effective systemic therapies. The development of targeted agents inhibiting tumor angiogenesis has emerged as a promising strategy, particularly those…
Nemaline myopathy (NM) is a genetically heterogeneous congenital myopathy defined by muscle weakness and the presence of nemaline bodies—rod-like structures derived from Z-disk abnormalities in skeletal muscle fibers. While mutations…
Methadone’s ability to inhibit chloride currents in intestinal epithelial cells has been linked to its interference with lubiprostone-mediated activation of ClC-2 channels. This study focused on elucidating the molecular mechanism…
The development of tumor angiogenesis is a critical step in cancer progression, enabling the growth and spread of malignant lesions. In this study, we investigated the role of miR-143 in…