PIK-93
PIK-93 is an inhibitor of PI3K that exhibits some selectivity for p110α and p110γ. PIK-93 also inhibits PI4KIIIβ, a phosphatidylinositol enzyme similar to PI3K. PIK-93 decreases translocation of transient receptor potential canonical 6 channel (TRPC6) to the plasma membrane in vitro and may alter Ca2+ signaling as a result.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954462
| Cas No. |
593960-11-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H16ClN3O4S2 |
| Formula Wt. |
389.88 |
| IUPAC Name |
N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide |
| Synonym |
PIK93 |
| Appearance |
Off-white Powder |
Monet M, Francoeur N, Boulay G. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012 May 18;287(21):17672-81. PMID: 22493444.
