PF-06447475
PF-06447475 inhibits leucine-rich repeat kinase 2 (LRRK2), exhibiting neuroprotective activity. In animal models of Parkinson’s disease, this compound suppresses neuroinflammation and neurodegeneration.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953056
| Cas No. |
1527473-33-1 |
|---|---|
| Formula |
C17H15N5O |
| Formula Wt. |
305.13 |
| IUPAC Name |
3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile |
Daher JP, Abdelmotilib HA, Hu X, et al. LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration. J Biol Chem. 2015 Jun 15. [Epub ahead of print]. PMID: 26078453.
Henderson JL, Kormos BL, Hayward MM, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. PMID: 25353650.
