BML-277
BML-277 is an arylbenzimidazole inhibitor of checkpoint kinase 2 (CHK2). This compound displays cytoprotective activity, protecting CD4+ and CD8+ T cells against radiation-induced apoptosis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18844771
| Cas No. |
516480-79-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H14ClN3O2 |
| Formula Wt. |
363.80 |
| IUPAC Name |
2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide |
Arienti KL, Brunmark A, Axe FU, et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. PMID: 15771432.
