Spontaneous preterm birth remains the leading cause of neonatal mortality and long-term neurological disabilities among survivors. A significant proportion of these cases are linked to intrauterine infection, which triggers a robust inflammatory response. This cascade activates multiple pathways culminating in myometrial contractions and rupture of fetal membranes—key events in labor initiation. In non-gestational tissues, the citrus flavone nobiletin has demonstrated potent anti-inflammatory effects. This study aimed to evaluate whether nobiletin could modulate pro-inflammatory and pro-labour mediators in human fetal membranes and myometrium exposed to bacterial endotoxin lipopolysaccharide (LPS). Additionally, its effects were assessed in fetal membranes obtained from women who experienced spontaneous preterm birth with or without histological chorioamnionitis.
Human fetal membranes and myometrial tissues were treated with LPS in the presence or absence of nobiletin. In both tissue types, nobiletin significantly suppressed LPS-induced expression of key pro-inflammatory cytokines—TNF-α, IL-1β, IL-6, and IL-8—as well as matrix metalloproteinase-9 (MMP-9) mRNA levels and secreted pro-MMP-9. Furthermore, nobiletin markedly reduced COX-2 expression and subsequent prostaglandin E₂ (PGE₂) production in myometrial tissues.Tolvaptan References Notably, nobiletin also attenuated the expression and secretion of these inflammatory markers in fetal membranes isolated from spontaneous preterm deliveries, regardless of infection status.4-Methylphthalic anhydride medchemexpress These findings indicate that nobiletin effectively dampens infection-driven inflammation in gestational tissues.PMID:35073864
The results support the growing body of evidence linking high fruit and vegetable intake during pregnancy with reduced risk of adverse outcomes. Given its superior bioavailability compared to other phytophenols, nobiletin represents a promising dietary compound with potential therapeutic value in preventing or delaying preterm birth. By targeting multiple inflammatory pathways central to labor initiation, nobiletin may serve as a safe and effective agent to mitigate the risks associated with premature delivery.MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com