Name :
Recombinant Mouse EphA3 Protein (aa 569-984)
Biological Activity :
Background :
EphA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA3 gene encodes a protein that binds ephrin-A ligands. EphA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Biological Activity :
Kinase activity untested
Expression Host :
Mouse
Source :
Baculovirus-Insect Cells
Tag :
Protein Accession No. :
EDK98238.1
NCBI Gene ID :
Synonyms :
Synonyms :
EPH receptor A3
Amino Acid Sequence :
Molecular Weight :
The recombinant mouse EphA3 consists of 418 amino acids and has a calculated molecular mass of 46.6 kDa. The recombinant protein migrates as an approximately 44 kDa band in SDS-PAGE under reducing conditions.
Purity :
> 85 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg of the protein as determined by the LAL method
Protein Construction :
A DNA sequence encoding the mouse EphA3 (EDK98238.1) (Gly569-Val984) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus.
Buffer Solution :
Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Redissolution :
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Synonyms :
AW492086 Protein, Mouse; Cek4 Protein, Mouse; End3 Protein, Mouse; ETK1 Protein, Mouse; Hek Protein, Mouse; Hek4 Protein, Mouse; Mek4 Protein, Mouse; Tyro4 Protein, Mouse EphA3 背景信息 EphA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA3 gene encodes a protein that binds ephrin-A ligands. EphA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
References & Citations :
Holder N, et al. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development. 126(10):2033-44. Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196:177-244. Xu Q, et al. (2001) Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 355(1399):993-1002. (function()if (!document.body) return;var js = “window[‘__CF$cv$params’]=r:’86b4219aeeb35fee’,t:’MTcxMTU5MjMyNC40NDgwMDA=’;_cpo=document.createElement(‘script’);_cpo.nonce=”,_cpo.src=’/cdn-cgi/challenge-platform/scripts/jsd/main.js’,document.getElementsByTagName(‘head’)[0].appendChild(_cpo);”;var _0xh = document.createElement(‘iframe’);_0xh.height = 1;_0xh.width = 1;_0xh.style.position = ‘absolute’;_0xh.style.top = 0;_0xh.style.left = 0;_0xh.style.border = ‘none’;_0xh.style.visibility = ‘hidden’;document.body.appendChild(_0xh);function handler() var _0xi = _0xh.contentDocument if (document.readyState !== ‘loading’) handler(); else if (window.addEventListener) document.addEventListener(‘DOMContentLoaded’, handler); else function () ;document.onreadystatechange = function (e) prev(e);if (document.readyState !== ‘loading’) document.onreadystatechange = prev;handler();;)();
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