Mouse IL-31 RA Protein 3955

Additional Information:
accession Q8K5B1|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundInterleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.|molecular weightThe protein has a predicted MW of 56.3 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse IL-31 RAProtein 3955proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceInterleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.Protein namesInterleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (GLM-R) (mGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (Novel cytokine receptor 10) (NR10) (ZcytoR17)Gene namesIl31ra,Il31ra GlmrProtein familyType I cytokine receptor family, Type 2 subfamilyMass10090DaFunctionAssociates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).Subellular locationCell membrane ; Single-pass type I membrane protein. Presynaptic cell membrane. Cell projection, axon .TissuesExpressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896).StructureHeterodimer with OSMR. Interacts with JAK1 and STAT3.Post-translational modificationN-glycosylated.Target Relevance information above includes information from UniProt accession: Q8K5B1The UniProt Consortium|