Human MOG/Myelin Oligodendrocyte Glycoprotein Protein 3463

Additional Information:
accession Q16653|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundMyelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM).|molecular weightThe protein has a predicted MW of 15.4 kDa. Due to glycosylation, the protein migrates to 20-23 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human MOG/Myelin Oligodendrocyte Glycoprotein Protein 3463proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceMyelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM).Protein namesMyelin-oligodendrocyte glycoproteinGene namesMOG,MOGProtein familyImmunoglobulin superfamily, BTN/MOG familyMass9606DaFunctionMediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.; (Microbial infection) Acts as a receptor for rubella virus.Subellular location[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 5]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 6]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 7]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 9]: Cell membrane ; Single-pass type I membrane protein .TissuesFound exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.StructureHomodimer (By similarity). May form heterodimers between the different isoforms (By similarity).; (Microbial infection) Interacts with rubella virus E2 glycoprotein.Target Relevance information above includes information from UniProt accession: Q16653The UniProt Consortium|