Product Name :
Ro-51
Description:
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
CAS:
1050670-85-3
Molecular Weight:
474.29
Formula:
C17H23IN4O4
Chemical Name:
2-(4-amino-5-[5-iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidin-2-ylamino)propane-1,3-diol
Smiles :
CC(C)C1=CC(OC)=C(I)C=C1OC1=CN=C(NC(CO)CO)N=C1N
InChiKey:
PAYROHWFGZADBR-UHFFFAOYSA-N
InChi :
InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.1-(4-Bromophenyl)piperazine supplier
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.D-Pantothenic acid Epigenetics
Additional information:
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.|Product information|CAS Number: 1050670-85-3|Molecular Weight: 474.29|Formula: C17H23IN4O4|Chemical Name: 2-(4-amino-5-[5-iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidin-2-ylamino)propane-1,3-diol|Smiles: CC(C)C1=CC(OC)=C(I)C=C1OC1=CN=C(NC(CO)CO)N=C1N|InChiKey: PAYROHWFGZADBR-UHFFFAOYSA-N|InChi: InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35164752 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM. RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3).|In Vivo:|Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat.|Products are for research use only. Not for human use.|