Et al. BMC Genomics 2014, 15:159 http:www.biomedcentral.com1471-216415Page 13 ofDSA performed the microarray hybridization evaluation. DSA conceived from the study, participated in its design and style and coordination and helped to draft the manuscript. All authors read and approved the final manuscript. Acknowledgements Supported by National Institutes of Health grant R21AI075237 and R01AI072297 to DSA. The authors thank Jay Card for photography and illustration help. Author details 1 Department of Pathology 2-Cyanopyrimidine supplier Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0529, USA. two Division of Biomedical Informatics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA. 3The J. Craig Venter Institute, 9704 Medical Center Drive, Sulfaquinoxaline Anti-infection Rockville, MD 20850, USA. 4Department of Pathology, University of Cincinnati, PO Box 670529, Cincinnati, OH 45267-0529, USA. Received: 17 October 2013 Accepted: 17 February 2014 Published: 25 February 2014 References 1. Shoham S, Marr KA: Invasive fungal infections in strong organ transplant recipients. Future Microbiol 2012, 7(five):63955. two. Segal BH: Aspergillosis. N Engl J Med 2009, 360(18):1870884. three. Kim A, Nicolau DP, Kuti JL: Hospital costs and outcomes among intravenous antifungal therapies for individuals with invasive Aspergillosis in the United states of america. Mycoses 2011, 54(5):e30112. four. Wilson LS, Reyes CM, Stolpman M, Speckman J, Allen K, Beney J: The direct expense and incidence of systemic fungal infections. Value Overall health 2002, five(1):264. five. Lin SJ, Schranz J, Teutsch SM: Aspergillosis case-fatality rate: systematic review on the literature. Clin Infect Dis 2001, 32(3):35866. 6. Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, PowersFletcher MV, Zhang M, Fuller KK, Nierman WC, et al: HacA-independent functions on the ER anxiety sensor IreA synergize with all the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 2011, 7(10):e1002330. 7. Richie DL, Hartl L, Aimanianda V, Winters MS, Fuller KK, Miley MD, White S, McCarthy JW, Latge JP, Feldmesser M, et al: A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus. PLoS Pathog 2009, 5(1):e1000258. 8. Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA: Exclusive evolution of the UPR pathway using a novel bZIP transcription aspect, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 2011, 7(eight):e1002177. 9. Joubert A, Simoneau P, Campion C, Bataille-Simoneau N, Iacomi-Vasilescu B, Poupard P, Francois JM, Georgeault S, Sellier E, Guillemette T: Impact in the unfolded protein response around the pathogenicity of your Neurotrophic fungus Alternaria brassicicola. Mol Microbiol 2011, 79(five):1305324. 10. Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H, Kohno S: Dissection of Ire1 functions reveals tension response mechanisms uniquely evolved in Candida glabrata. PLoS Pathog 2013, 9(1):e1003160. 11. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P: Endoplasmic reticulum tension sensing in the unfolded protein response. Cold Spring Harbor Perspect Biol 2013, 5(three):a013169. 12. Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJ, Archer DB: Effect of your unfolded protein response upon genome-wide expression patterns, as well as the role of Hac1 inside the polarized growth, of Candida albicans. Fungal Genet Biol 2008, 45(9):1235247. 13. Hartmann T, Sasse C, Schedler A, Hasenbe.
