Et al. BMC Genomics 2014, 15:159 http:www.biomedcentral.com1471-216415Page 13 ofDSA performed the microarray hybridization evaluation. DSA conceived in the study, participated in its style and coordination and helped to draft the manuscript. All authors read and authorized the final manuscript. Acknowledgements Supported by National Institutes of Wellness grant R21AI075237 and R01AI072297 to DSA. The authors thank Jay Card for photography and illustration help. Author information 1 Division of Pathology Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0529, USA. two Division of Difenoconazole site Biomedical Informatics, Cincinnati Children’s Hospital Investigation Foundation, Cincinnati, OH 45229, USA. 3The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA. 4Department of Pathology, University of Cincinnati, PO Box 670529, Cincinnati, OH 45267-0529, USA. Received: 17 October 2013 Accepted: 17 February 2014 Published: 25 February 2014 References 1. Shoham S, Marr KA: Invasive fungal infections in solid organ transplant recipients. Future Microbiol 2012, 7(5):63955. two. Segal BH: Aspergillosis. N Engl J Med 2009, 360(18):1870884. three. Kim A, Nicolau DP, Kuti JL: Hospital costs and outcomes amongst intravenous antifungal therapies for patients with invasive Aspergillosis inside the United states. Mycoses 2011, 54(five):e30112. four. Wilson LS, Reyes CM, Stolpman M, Speckman J, Allen K, Beney J: The direct cost and incidence of systemic fungal infections. Value Health 2002, five(1):264. five. Lin SJ, Schranz J, Teutsch SM: Aspergillosis case-fatality price: systematic overview with the literature. Clin Infect Dis 2001, 32(3):35866. 6. Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, PowersFletcher MV, Zhang M, Fuller KK, Nierman WC, et al: HacA-independent functions in the ER stress sensor IreA synergize with all the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 2011, 7(10):e1002330. 7. Richie DL, Hartl L, Aimanianda V, Winters MS, Fuller KK, Miley MD, White S, McCarthy JW, Latge JP, Feldmesser M, et al: A function for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus. PLoS Pathog 2009, five(1):e1000258. eight. Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA: Exclusive evolution of the UPR pathway having a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 2011, 7(eight):e1002177. 9. Joubert A, Simoneau P, Campion C, Bataille-Simoneau N, Iacomi-Vasilescu B, Poupard P, Francois JM, Georgeault S, Sellier E, Guillemette T: Effect on the unfolded protein response around the pathogenicity with the Neurotrophic fungus Alternaria brassicicola. Mol Microbiol 2011, 79(five):1305324. ten. Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H, Kohno S: Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida Valiolamine custom synthesis glabrata. PLoS Pathog 2013, 9(1):e1003160. 11. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P: Endoplasmic reticulum pressure sensing inside the unfolded protein response. Cold Spring Harbor Perspect Biol 2013, 5(3):a013169. 12. Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJ, Archer DB: Effect of the unfolded protein response upon genome-wide expression patterns, and also the part of Hac1 in the polarized development, of Candida albicans. Fungal Genet Biol 2008, 45(9):1235247. 13. Hartmann T, Sasse C, Schedler A, Hasenbe.
